Optimal [18] F-Misonidazole PET threshold to locate SCC7 tumor hypoxia using EPR pO2 as ground truth

I Gertsenshteyn, E Barth, H Kim, B Epel, L Leoni… - 2021 - Soc Nuclear Med
12 Objectives: Tumor hypoxia is associated with resistance to therapy and tumor
progression, and correlates negatively with patient survival [1, 2, 3]. 18 F-Misonidazole …

The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance …

I Gertsenshteyn, B Epel, A Ahluwalia, H Kim… - European journal of …, 2022 - Springer
Purpose To identify the optimal threshold in 18F-fluoromisonidazole (FMISO) PET images to
accurately locate tumor hypoxia by using electron paramagnetic resonance imaging (pO2 …

Preliminary Investigation of Hypoxia within Tumor Using EPRI, DCE-MRI, and PET-CT with 18F-FMISO to Improve Radiotherapy

I Gertsenshteyn, B Epel, M Giurcanu, L Leoni, E Barth… - 2019 - Soc Nuclear Med
347 Objectives: Hypoxic cells are more resistant than normoxic cells to radiation treatment,
so the identification of hypoxic regions within the tumor is necessary to predict or improve …

Kinetic modeling of [18F]-FMISO microPET data and its correlation with image-guided pO2 measurements

R Bartlett, P Zanzonico, S Carlin, Q Chen, G Roble… - 2010 - Soc Nuclear Med
232 Objectives Hypoxia increases resistance to treatment and may predict tumor
progression. Non-invasive methods to determine intra-tumor hypoxia, such as PET, are …

Development of a PET/EPRI simultaneous imaging system for assessing tumor hypoxia

H Kim, B Epel, S Sundramoorthy, HM Tsai, E Barth… - 2019 - Soc Nuclear Med
526 Objectives: Quantitative assessment of tumor hypoxia [1] is important in cancer
treatment and therapeutic planning. 18 F-fluoromisonidazole (F-MISO)[2] and 64 Cu-ATSM …

Quantification of Tumor Hypoxic Fractions Using Positron Emission Tomography with [18F]Fluoromisonidazole ([18F]FMISO) Kinetic Analysis and Invasive Oxygen …

OJ Kelada, S Rockwell, MQ Zheng, Y Huang… - Molecular imaging and …, 2017 - Springer
Purpose The purpose of this study is to use dynamic [18 F] fluoromisonidazole ([18 F]
FMISO) positron emission tomography (PET) to compare estimates of tumor hypoxic …

Quantitative Analysis of [18F]FMISO PET for Tumor Hypoxia: Correlation of Modeling Results with Immunohistochemistry

K Shi, C Bayer, ST Astner, FC Gaertner… - Molecular imaging and …, 2017 - Springer
Purpose Quantitative evaluation of tumor hypoxia based on H-1-(3-[18 F] fluoro-2-
hydroxypropyl)-2-nitroimidazole ([18 F] FMISO) positron emission tomography (PET) can …

Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic …

I Gertsenshteyn, B Epel, E Barth, L Leoni… - Radiology: Imaging …, 2021 - pubs.rsna.org
Purpose To enhance the spatial accuracy of fluorine 18 (18F) misonidazole (MISO) PET
imaging of hypoxia by using dynamic contrast-enhanced (DCE) MR images as a basis for …

A PET/EPR simultaneous imaging system for assessing tumor hypoxia: development and initial imaging results

H Kim, B Epel, S Sundramoorthy… - 2019 IEEE Nuclear …, 2019 - ieeexplore.ieee.org
We present a combined imaging system of positron emission tomography (PET) and
electron paramagnetic resonance imaging (EPRI) developed for assessing tumor hypoxia …

[HTML][HTML] 18F-Fluoromisonidazole in tumor hypoxia imaging

Z Xu, XF Li, H Zou, X Sun, B Shen - Oncotarget, 2017 - ncbi.nlm.nih.gov
Hypoxia is a common feature of solid tumors that is closely associated with radiotherapy and
chemotherapy resistance, metastasis and tumors prognosis. Thus, it is important to assess …