Specific and rapid scintigraphic detection of infection with 99mTc-labeled interleukin-8
HJJM Rennen, OC Boerman, WJG Oyen… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Interleukin-8 (IL-8) is a chemotactic cytokine involved in activation and recruitment of
neutrophils to areas of infection. In our previous studies in rabbits we tested 123I-labeled IL …
neutrophils to areas of infection. In our previous studies in rabbits we tested 123I-labeled IL …
99mTc-labeled interleukin 8 for the scintigraphic detection of infection and inflammation: first clinical evaluation
CP Bleeker-Rovers, HJJM Rennen… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Interleukin 8 (IL-8) is a chemotactic cytokine that binds with a high affinity to receptors
expressed on neutrophils. Previous studies with various animal models showed that 99mTc …
expressed on neutrophils. Previous studies with various animal models showed that 99mTc …
The kinetics of radiolabelled interleukin-8 in infection and sterile inflammation
CJ Van der Laken, OC Boerman… - Nuclear medicine …, 1998 - journals.lww.com
Abstract Radiolabelled interleukin-8 (IL-8) is a promising, agent for the imaging of infection
and inflammation. Several experiments were performed to explore further the imaging …
and inflammation. Several experiments were performed to explore further the imaging …
Kinetics of 99mTc-labeled interleukin-8 in experimental inflammation and infection
HJJM Rennen, OC Boerman, WJG Oyen… - Journal of Nuclear …, 2003 - Soc Nuclear Med
The cytokine interleukin-8 (IL-8) binds with high affinity to the CXCR1 and CXCR2 receptors
on neutrophils. In previous studies, we showed that 99mTc-IL-8 could rapidly and effectively …
on neutrophils. In previous studies, we showed that 99mTc-IL-8 could rapidly and effectively …
99mTc-labeled interleukin-8 for scintigraphic detection of pulmonary infections
HJJM Rennen, CP Bleeker-Rovers, C Frielink… - Chest, 2004 - Elsevier
Background: Interleukin (IL)-8 is a chemotactic cytokine that binds with high affinity to
receptors on neutrophils. Previously we showed that 99m Tc-labeled IL-8 is highly suitable …
receptors on neutrophils. Previously we showed that 99m Tc-labeled IL-8 is highly suitable …
[PDF][PDF] Radiolabeled interleukin-8: specific scintigraphic detection of infection within a few hours
CJ van der Laken, OC Boerman… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Several small receptor-binding agents have been tested for imagingof infectionand
inflammation. The potentialof chemotac tic peptidesand of interleukinsis promisingand …
inflammation. The potentialof chemotac tic peptidesand of interleukinsis promisingand …
Specific targeting of infectious foci with radioiodinated human recombinant interleukin-1 in an experimental model
CJ van der Laken, OC Boerman, WJG Oyen… - European journal of …, 1995 - Springer
In the present study, radioiodinated human recombinant interleukin-1 (IL-1) was investigated
for its potential to image infectious foci in vivo in an animal model of infection. Twenty-four …
for its potential to image infectious foci in vivo in an animal model of infection. Twenty-four …
Imaging of human infection with 131I-labeled recombinant human interleukin-8
MD Gross, B Shapiro, LM Fig, R Steventon… - Journal of Nuclear …, 2001 - Soc Nuclear Med
The chemotactic cytokine interleukin-8 (IL-8) plays an important role in attraction and
activation of polymorphonuclear leukocytes in infection and inflammation. A pilot study was …
activation of polymorphonuclear leukocytes in infection and inflammation. A pilot study was …
The development of technetium-99m-labelled interleukin-2: a new radiopharmaceutical for the in vivo detection of mononuclear cell infiltrates in immune-mediated …
M Chianelli, A Signore, AR Fritzberg… - Nuclear medicine and …, 1997 - Elsevier
We describe here a new method for labelling interleukin-2 (IL-2) in high specific activity with
99mTc for in vivo studies in man. Labelling was performed via a two-step reaction using an …
99mTc for in vivo studies in man. Labelling was performed via a two-step reaction using an …
Rapid imaging of experimental colitis with 99mTc-interleukin-8 in rabbits
S Gratz, HJJM Rennen, OC Boerman… - Journal of Nuclear …, 2001 - Soc Nuclear Med
Radiolabeled autologous leukocytes (WBCs) are the gold standard for imaging inflammatory
bowel disease (IBD). For the rapid and adequate management of patients with IBD, there is …
bowel disease (IBD). For the rapid and adequate management of patients with IBD, there is …
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