Recently, we developed a physiologically based pharmacokinetic model capable of
predicting antibody biodistribution in humans by scaling up from mice. By applying this …

Antibodies can be used to carry radionuclides to tumors for in vivo diagnosis and treatment.
Monoclonal antibody reagents have virtually replaced the heterosera of earlier days. When …

The limited success of the sole use of monoclonal antibodies for cancer detection and
treatment has led to the development of multistep methods using antibodies in conjunction …

Four basic science articles and two special contributions included in this issue of the journal
address some of the persistent challenges that continue to moderate the progress of …

Radioimmunotherapy is a method to selectively deliver radioactivity to cancer cells via
specific antibodies. A strategy to enhance the efficacy of radioimmunotherapy is the prior …

Recently, it has been suggested that the concept of preloading is limited by using a standard
amount of unlabeled antibody. To identify the potential of optimal preloading, a …

Lntibody molecules are very complex structures, grouped into five distinct classes; IgG, IgA,
IgM, IgE, IgD. These classes differ from each other in size, charge, amino acid composition …

In contrast to the overwhelming success of radiolabeled antibodies in treating hematologic
malignancies, only modest success has been achieved in the radioimmunotherapy of solid …

This review focuses on the use of radiolabeled antibodies in the therapy of cancer, termed
radioimmunotherapy (RAIT). Basic problems concerned with the choice of antibody …

This chapter reviews the current status, including major accomplishments, technical
problems and some proposed strategies, of the targeting of tumors with radiolabeled …