Small-animal PET imaging of pancreatic cancer xenografts using a 64Cu-labeled monoclonal antibody, MAb159
H Wang, D Li, S Liu, R Liu, H Yuan… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Overexpression of the GRP78 receptor on cell surfaces has been linked with tumor growth,
metastasis, and resistance to therapy. We developed a 64Cu-labeled probe for PET imaging …
metastasis, and resistance to therapy. We developed a 64Cu-labeled probe for PET imaging …
Synthesis and Preclinical Evaluation of [68Ga]SP94 for Micro-PET Imaging of GRP78 Expression in Hepatocellular Carcinoma
Y Xu, J Jiang, H Wang, W Yu, G Sun - ACS Medicinal Chemistry …, 2021 - ACS Publications
Glucose-regulated protein 78 (GRP78) is overexpressed in a wide variety of solid tumors,
serving as a well-characterized target for tumor imaging or therapy. In this work, we …
serving as a well-characterized target for tumor imaging or therapy. In this work, we …
GRP receptor-targeted PET of a rat pancreas carcinoma xenograft in nude mice with a 68Ga-labeled bombesin (6–14) analog
J Schuhmacher, H Zhang, J Doll… - Journal of nuclear …, 2005 - Soc Nuclear Med
Bombesin (BN), a 14-amino-acid peptide, shows high affinity for the human gastrin-
releasing peptide receptor (GRP-r), which is overexpressed on several types of cancer …
releasing peptide receptor (GRP-r), which is overexpressed on several types of cancer …
[HTML][HTML] Preclinical evaluation of the copper-64 labeled GRPR-antagonist RM26 in comparison with the cobalt-55 labeled counterpart for PET-imaging of prostate …
C Baun, B Mitran, SS Rinne, JH Dam, BB Olsen… - Molecules, 2020 - mdpi.com
Gastrin-releasing peptide receptor (GRPR) is overexpressed in the majority of prostate
cancers. This study aimed to investigate the potential of 64Cu (radionuclide for late time …
cancers. This study aimed to investigate the potential of 64Cu (radionuclide for late time …
Evaluation of a novel GRPR antagonist for prostate cancer PET imaging:[64Cu]-DOTHA2-PEG-RM26
N Mansour, M Paquette, S Ait-Mohand… - Nuclear Medicine and …, 2018 - Elsevier
Introduction Gastrin releasing peptide receptors (GRPRs) are significantly over-expressed
on a large proportion of prostate cancers making them prime candidates for receptor …
on a large proportion of prostate cancers making them prime candidates for receptor …
[HTML][HTML] 66Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [66Ga]Ga-NOTA-PEG2-RM26
Molecular imaging of the gastrin-releasing peptide receptor (GRPR) could improve patient
management in prostate cancer. This study aimed to produce gallium-66 (T½= 9.5 h) …
management in prostate cancer. This study aimed to produce gallium-66 (T½= 9.5 h) …
A Radiotracer for molecular imaging and therapy of gastrin-releasing peptide receptor–positive prostate cancer
The gastrin-releasing peptide receptor (GRPR) is overexpressed in many solid
malignancies, particularly in prostate and breast cancers, among others. We synthesized …
malignancies, particularly in prostate and breast cancers, among others. We synthesized …
GRP78 targeting: Hitting two birds with a stone
AA Elfiky, AM Baghdady, SA Ali, MI Ahmed - Life sciences, 2020 - Elsevier
Background Glucose regulating protein 78 (GRP78) is one member of the Heat Shock
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …
Protein family of chaperone proteins (HSPA5) found in eukaryotes. It acts as the master of …
microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3] bombesin in human prostate adenocarcinoma xenografts
X Chen, R Park, Y Hou, M Tohme… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Overexpression of gastrin-releasing peptide (GRP) receptor (GRPR) in both androgen-
dependent (AD) and androgen-independent (AI) human neoplastic prostate tissues provides …
dependent (AD) and androgen-independent (AI) human neoplastic prostate tissues provides …
Glypican-3–targeted 89Zr PET imaging of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a devastating malignancy in which imperfect imaging
plays a primary role in diagnosis. Glypican-3 (GPC3) is an HCC-specific cell surface …
plays a primary role in diagnosis. Glypican-3 (GPC3) is an HCC-specific cell surface …
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