Performing longitudinal quantitative PET studies in rats is routinely feasible

HM Wu, CH Wu, YY Huang, ML Tsai, SF Chen… - 2016 - Soc Nuclear Med
1899 Objectives In the past, performing quantitative small animal PET study with arterial
input function was technically challenging. Here, we report a procedure how we prepared a …

Performing repeated quantitative small-animal PET with an arterial input function is routinely feasible in rats

CC Huang, CH Wu, YY Huang, KY Tzen… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Performing quantitative small-animal PET with an arterial input function has been
considered technically challenging. Here, we introduce a catheterization procedure that …

Optimizing the total scanning time needed for quantitative mouse brain FDG-PET studies

HD Lin, A Yu, J Leong, SC Huang, M Phelps, HM Wu - 2007 - Soc Nuclear Med
330 Objectives: The small animal PET imaging shows capability of studying diseases using
transgentic animals. Routinely, 60-min scan adopted from human brain FDG-PET studies is …

In vivo quantitation of glucose metabolism in mice using small-animal PET and a microfluidic device

HM Wu, G Sui, CC Lee, ML Prins… - Journal of Nuclear …, 2007 - Soc Nuclear Med
The challenge of sampling blood from small animals has hampered the realization of
quantitative small-animal PET. Difficulties associated with the conventional blood-sampling …

A novel tracer injection system for PET imaging of small animals

HD Lin, R Silverman, A Yu, J Leong, SC Huang… - 2007 - Soc Nuclear Med
164 Objectives: Small animal PET imaging has been used to investigate the
pharmacokinetics and biochemistry in vivo in small animals. The radiotracer is usually …

Mapping changes in mouse brain metabolism with PET/CT

A Welch, M Mingarelli, G Riedel… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Because preclinical imaging offers challenges and opportunities, we set out to investigate
and optimize image processing techniques to measure changes in mouse brain metabolism …

Continuous infusion PET with constant input function

V Keereman, P van Mierlo, B Descamps… - 2013 - Soc Nuclear Med
2045 Objectives Quantitative dynamic PET imaging of radiotracer pharmacokinetics requires
knowledge of the arterial blood concentration of the radiotracer, usually determined using …

The feasibility of performing longitudinal measurements in mice using small animal PET imaging and a microfluidic blood sampling device

HM Wu, SY Amy, HD Lin, W Ladno… - 2007 IEEE Nuclear …, 2007 - ieeexplore.ieee.org
To minimize blood loss in a mouse during quantitative PET imaging, we developed an
automated blood sampling device using microfluidic technology. The integrated technology …

Derivation of input function for FDG-PET studies in mice with intraperitoneal injection

KP Wong, X Zhang, G Ferl, HD Lin, A Yu, HM Wu… - 2009 - Soc Nuclear Med
648 Objectives To derive the plasma time-activity curve in mouse PET studies with
intraperitoneal (IP) injection of FDG. Methods In 4 C57BL/6 isoflurane anesthetized mice …

Arterial blood sampling changes the steady state of glucose in rats during FDG-PET

IB del Re, HM Wu - 2010 - Soc Nuclear Med
1745 Objectives Metabolic rate of glucose (MR) can be measured using quantitative FDG-
PET. The method assumes that plasma glucose is at steady state throughout the scan and a …