Longitudinal evaluation of both morphologic and functional changes in the same individuals with Alzheimer's disease

H Matsuda, N Kitayama, T Ohnishi… - Journal of Nuclear …, 2002 - Soc Nuclear Med
Morphologic and functional imaging studies have not always given concordant results about
brain areas showing atrophic changes and reduced flow or metabolism in Alzheimer's …

[PDF][PDF] Parametric mapping of cerebral blood flow deficits in Alzheimer's disease: a SPECT study using HMPAO and image standardization technique

MB Imran, R Kawashima, S Awata, K Sato… - Journal of Nuclear …, 1999 - Soc Nuclear Med
RESULTS The inaccuracy index for AIR calculated on CBF images (based on voxel data)
was 1.8% ±0.11% and 2.3% ±0.28% for healthy subjects and AD patients, respectively …

Decreased cerebral blood flow and prognosis of Alzheimer's disease: a multicenter HMPAO-SPECT study

T Nishimura, K Hashikawa, H Fukuyama… - Annals of nuclear …, 2007 - Springer
Purpose: To determine the usefulness of brain perfusion SPECT for evaluating the severity
and progression of Alzheimer's disease (AD). Methods: Eighty-four AD patients were …

Regional cerebral blood flow abnormalities in nondemented patients with memory impairment

M Tanaka, H Fukuyama, H Yamauchi… - Journal of …, 2002 - Wiley Online Library
Background. Patients with objective evidence of memory impairment have been considered
to be at risk for developing Alzheimer's disease (AD). However, little is known about patterns …

[PDF][PDF] Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT

D Kogure, H Matsuda, T Ohnishi, T Asada… - Journal of nuclear …, 2000 - Soc Nuclear Med
The aim of this SPECT study was to determine the initial abnormality and longitudinal
changes in regional cerebral blood flow (rCBF) in early Alzheimer's disease (AD) using …

The effect of education on rCBF changes in Alzheimer's disease: a longitudinal SPECT study

H Hanyu, T Sato, S Shimizu, H Kanetaka… - European Journal of …, 2008 - Springer
Purpose To determine the relationship of differing levels of education on regional cerebral
blood flow (rCBF) in patients with Alzheimer's disease (AD). Methods Fifty-three patients with …

Cerebral blood flow is an earlier indicator of perfusion abnormalities than cerebral blood volume in Alzheimer's disease

M Lacalle-Aurioles, JM Mateos-Pérez… - Journal of Cerebral …, 2014 - journals.sagepub.com
The purpose of this study was to elucidate whether cerebral blood flow (CBF) can better
characterize perfusion abnormalities in predementia stages of Alzheimer's disease (AD) …

Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal …

AR Varma, W Adams, JJ Lloyd… - Acta neurologica …, 2002 - Wiley Online Library
Objectives–Alzheimer's disease (AD), frontotemporal dementia (FTD) and vascular
dementia (VaD) are the three most common causes of young onset dementias. Most …

The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study

H Hanyu, T Sato, K Hirao, H Kanetaka… - Journal of the …, 2010 - Elsevier
BACKGROUND AND PURPOSE: The progression of cognitive deterioration in patients with
Alzheimer's disease (AD) is considerably variable. The ability to predict the progression rate …

MRI-guided SPECT perfusion measures and volumetric MRI in prodromal Alzheimer disease

G El Fakhri, MF Kijewski, KA Johnson… - Archives of …, 2003 - jamanetwork.com
Objective To identify group differences in the prodromal phase of Alzheimer disease (AD)
using quantitative single-photon emission computed tomography (SPECT) perfusion and …