Myocardial 11C-diacylglycerol accumulation and left ventricular remodeling in patients after myocardial infarction

H Otani, Y Kagaya, Y Imahori, S Yasuda… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Left ventricular (LV) remodeling after myocardial infarction (MI) is a maladaptive process that
increases the risk of heart failure and death. The myocardial phosphoinositide cycle, which …

Visualization of myocardial phosphoinositide turnover with 1-[1-11C]-butyryl-2-palmitoyl-rac-glycerol in rats with myocardial infarction

M Chida, Y Kagaya, Y Imahori… - Journal of Nuclear …, 2000 - Soc Nuclear Med
Phosphoinositide turnover mediates the signaling of angiotensin II, which plays a pivotal
role in ventricular remodeling after myocardial infarction (MI). We tested the hypothesis that …

Myocardial lipid turnover in dilated cardiomyopathy: a dual in vivo tracer approach

LE Feinendegen, MM Henrich, JT Kuikka… - Journal of Nuclear …, 1995 - Springer
Background Myocardial lipid metabolism appears abnormal in dilated cardiomyopathy
(DCM). A dual-tracer approach with two different fatty acid analogs may allow us to observe …

Effect of angiotensin converting enzyme inhibition on myocardial phosphoinositide metabolism visualised with 1-[1-11C]-butyryl-2-palmitoyl-rac-glycerol in …

Y Kagaya, M Chida, Y Imahori, R Fujii… - European Journal of …, 2002 - Springer
We recently reported that myocardial phosphoinositide (PI) metabolism can be visualised by
1-[1-11 C]-butyryl-2-palmitoyl-rac-glycerol (11 C-DAG) in rats with myocardial infarction (MI) …

Assessment of myocardial triglyceride oxidation with PET and 11C-palmitate

Z Kisrieva-Ware, AR Coggan, TL Sharp… - Journal of nuclear …, 2009 - Elsevier
Background The goal of this study was to test whether myocardial triglyceride (TG) turnover
including oxidation of TG-derived fatty acids (FA) could be assessed with PET and 11 C …

Measurement of 1, 2-diacylglycerol and ceramide in hearts subjected to ischemic preconditioning

K Murase, K Okumura, K Hayashi, H Matsui, Y Toki… - Life Sciences, 2000 - Elsevier
An accumulation of recent evidence suggests that the mechanism in ischemic
preconditioning (IPC) may involve the activation of protein kinase C (PKC) regulatory …

1H NMR measurement of triacylglycerol accumulation in the post-ischemic canine heart after transient increase of plasma lipids

JA Balschi, JO Hai, PE Wolkowicz… - Journal of molecular and …, 1997 - Elsevier
This study tests the hypothesis that increased levels of plasma lipids can accelerate
accumulation of myocardial triacylglycerols in post-ischemic but viable myocardium. Two …

Brief preconditioning ischemia alters diacylglycerol content and composition in rabbit heart

A Gysembergh, A Zakaroff-Girard, J Loufoua… - Basic research in …, 2000 - Springer
In order to give further insight into the potential role of PKC in beneficial effects of ischemic
preconditioning, we have characterized the production of diacylglycerol, the endogenous …

Enhancing cardiac triacylglycerol metabolism improves recovery from ischemic stress

SC Kolwicz Jr, L Liu, IJ Goldberg, R Tian - Diabetes, 2015 - Am Diabetes Assoc
Elevated cardiac triacylglycerol (TAG) content is traditionally equated with cardiolipotoxicity
and suggested to be a culprit in cardiac dysfunction. However, previous work demonstrated …

Changes in distinct species of 1, 2-diacylglycerol in cardiac hypertrophy due to energy metabolic disorder

Y Saburi, K Okumura, H Matsui, K Hayashi… - Cardiovascular …, 2003 - academic.oup.com
Objective: The juvenile visceral steatosis (JVS) mouse, a genetic model of systemic carnitine
deficiency resulting from carnitine transport mutation, develops cardiac hypertrophy. We …