2-((1 E, 3 E)-4-(6-(11C-methylamino) pyridin-3-yl) buta-1, 3-dienyl) benzo [d] thiazol-6-ol
(11C-PBB3) is a clinically useful PET probe that we developed for in vivo imaging of tau …

Abstract Introduction [11 C] PBB3 is a clinically used positron emission tomography (PET)
probe for in vivo imaging of tau pathology in the brain. Our previous study showed that [11 C] …

Tau accumulation in the brain is a pathologic hallmark of Alzheimer disease and other
tauopathies. Quantitative visualization of tau pathology in humans can be a powerful method …

CBD-2115 was selected from a library of 148 compounds based on a pyridinyl-indole
scaffold as a first-in-class 4R-tau radiotracer. In vitro binding assays showed [3H] CBD-2115 …

Misfolding, aggregation, and cerebral accumulation of tau deposits are hallmark features of
Alzheimer's disease. Positron emission tomography study of tau can facilitate the …

In this study, we have synthesized and evaluated 18F-JNJ64349311, a tracer with high
affinity for aggregated tau (inhibition constant value, 8 nM) and high (≥ 500×) in vitro …

Neurofibrillary tangles in Alzheimer disease (AD) brains are composed of the microtubule-
associated protein tau. Noninvasive monitoring of tau protein aggregates in the living brain …

Purpose Several tau PET tracers have been developed, but it remains unclear whether they
bind to the same molecular target on the heterogeneous tau pathology. In this study we …

Tau aggregates and amyloid-β (Aβ) plaques are key histopathologic features in Alzheimer
disease (AD) and are considered targets for therapeutic intervention as well as biomarkers …

11C-RO-963, 11C-RO-643, and 18F-RO-948 (previously referred to as 11C-RO6924963,
11C-RO6931643, and 18F-RO6958948, respectively) have been reported as promising PET …