The induction of neuroinflammatory processes, characterized by upregulation of the
peripheral benzodiazepine receptor (PBR) expressed by microglial cells, is well correlated …

It is important to gain more insight into neurodegenerative diseases, because these
debilitating diseases can not be cured. A common characteristic of many neurological …

Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory
reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug …

The peripheral-type benzodiazepine receptors (PBRs) are only minimally expressed in
normal brain parenchyma, where they are primarily localized in glial cells. Their basal …

The peripheral benzodiazepine receptor (PBR) is expressed by microglial cells in many
neuropathologies involving neuroinflammation. PK11195, the reference compound for PBR …

Peripheral benzodiazepine receptors (PBRs) are upregulated on activated microglia. We
recently developed a promising positron emission tomography (PET) ligand,[11C] PBR28 …

Purpose The key role of neuroinflammation in acute and chronic neurological disorders has
stimulated the search for specific radiotracers targeting the peripheral benzodiazepine …

Developing a PET ligand for imaging of the peripheral benzodiazepine receptor (PBR;
Translocator Protein [18 kDa] TSPO) is of great importance for studying its role in glial cells …

Activated microglia are an important feature of many neurological diseases and can be
imaged in vivo using 1‐(2‐chlorophenyl)‐N‐methyl‐N‐(1‐methylpropyl)‐3 …

OBJECTIVES: Peripheral benzodiazepine receptors (PBRs) are upregulated on activated
microglia and are thereby biomarkers of neuroinflammation. We developed a PET ligand …