Myocardial infarction is associated with neuroinflammation-a systemic analysis using TSPO-targeted molecular imaging.

HC Hupe, J Thackeray, J Postema, Y Wang, TL Ross… - 2016 - Soc Nuclear Med
404 Objectives Acute myocardial infarction (MI) evokes local and systemic inflammation,
which may contribute to heart failure progression and cognitive decline. We aimed to assess …

[HTML][HTML] Angiotensin-converting enzyme inhibitor treatment early after myocardial infarction attenuates acute cardiac and neuroinflammation without effect on chronic …

T Borchert, A Hess, M Lukačević, TL Ross… - European journal of …, 2020 - Springer
Purpose Myocardial infarction (MI) triggers a local inflammatory response which
orchestrates cardiac repair and contributes to concurrent neuroinflammation. Angiotensin …

249 Serial 11C-methionine PET detects involvement of astroglia in neuroinflammation following acute myocardial infarction

P Bascunana Almarcha, A Hess… - European Heart …, 2019 - academic.oup.com
Background: Recent evidence indicates that acute myocardial infarction (MI) evokes
concurrent acute cardiac and neuroinflammation. 18F-GE180 PET imaging of the …

11C-methionine PET identifies astroglia involvement in heart–brain inflammation networking after acute myocardial infarction

P Bascuñana, A Hess, T Borchert, Y Wang… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Acute myocardial infarction (MI) triggers a local and systemic inflammatory response. We
recently showed microglia involvement using translocator protein imaging. Here, we …

Myocardial inflammation predicts remodeling and neuroinflammation after myocardial infarction

JT Thackeray, HC Hupe, Y Wang, JP Bankstahl… - Journal of the American …, 2018 - jacc.org
Background: The local inflammatory tissue response after acute myocardial infarction (MI)
determines subsequent healing. Systemic interaction may induce neuroinflammation as a …

2 TSPO PET imaging of inflammation with [18F] LW223 predicts functional outcome following myocardial infarction

J MacAskill, V Reid, C Alcaide-Corral, T Morgan… - 2023 - heart.bmj.com
Inflammation is a key process influencing left ventricular remodelling following myocardial
infarction (MI) and can be imaged using Positron Emission Tomography (PET) targeting the …

Impact of Acute Myocardial Infarction on Neuroinflammation and Alzheimer's Disease Pathology in a Transgenic Mouse Model

K Lolatte, M Brackhan, A Hess, PB Almarcha… - 2022 - Soc Nuclear Med
2299 Introduction: Myocardial infarction (MI) and progressive heart failure are associated
with a higher incidence of cognitive impairment and Alzheimer9s dementia. Acute and …

Molecular imaging of the brain-heart axis after stroke: Impact of regional microglia suppression on cardiac function

V Wroblewski, M Willmann, T Ross, F Bengel… - 2023 - Soc Nuclear Med
P922 Introduction: Cerebral stroke imparts local neuroinflammation and corresponds with an
acute and sustained decline in cardiac function. Our prior work revealed that regional …

Molecular imaging of inflammation in the brain-heart axis after ischemic stroke: comparison of two murine stroke models.

N Hermanns, P Bascunana, BLN Langer, B Wolf… - 2020 - Soc Nuclear Med
88 Introduction: In addition to neurologic dysfunction, cerebral stroke increases risk of acute
cardiac events and chronic heart failure. We hypothesized that inflammation is a linking …

[HTML][HTML] Molecular imaging of the brain–heart axis provides insights into cardiac dysfunction after cerebral ischemia

N Hermanns, V Wroblewski, P Bascuñana… - Basic Research in …, 2022 - Springer
Ischemic stroke imparts elevated risk of heart failure though the underlying mechanisms
remain poorly described. We aimed to characterize the influence of cerebral ischemic injury …