MATERIALS AND METHODS Patients. Fifty-eight patients (5 1 M, 7 F) were stud ied.
Informed consent was obtained when more than routine scintigraphic study was to be …

MATERIALS AND METHODS Cobalt-Si was obtained as 57CoC12, carrier free, 3 mCi/mI in
0.5 N HQ from Philips-Duphar, Petten, The Netherlands. Bleomycin was kindly supplied by …

DISTRIBUTION OF LABELED BLEOMYCIN IN NORMAL AND TUMOR-BEARING MICE Page 1
The chemotherapeutic drug bleomycin has been labeled with 57Co, 1111n, 67Ga, and 59Fe …

METHODS Labeling of BLEO was accomplished by adding 1 ml of 57Co (0.5 — 1mCi/mi)
or 1 ml of@ In (2 mCi/mi) in 0.5 N HC1 to 2 units of BLEO@ diluted in 2 ml of normal saline …

Bleomycin serves as a useful prototype for a study of the various properties required in a
radiopharmaceutical for tumor imaging. Both in vitro and in vivo results using bleomycin …

The chemical composition of bleomycin labelled with 57 Co and its distribution and kinetics
in the organs of tumour bearing rats were studied. For separating bleomycin, the …

Location OverallcasesMalignant 17 — chromatography using 1: 1 mixture of 75% methanol
and 10% ammonium acetate. The effect of labeling procedures on the antimicrobial activity …

MATERIALS AND METHODS Bleomycin A2 was coupled to human serum albu mm with l-
ethyl-3 (3-dimethylaminopropyl) carbodi imide (10). Fifty milligrams of human serum albu …

Investigations with bleomycin labelled with radionuclides other than 57 Co in patients with
cancer and in tumor-bearing animals are described. In patients 57 Co-bleo appears to be a …

Administered Dose and Tumor Dose of Bleomycin Labeled with Cobalt-57 in Mice and Men
Page 1 and the tumor dose, ie, that the administration of a high dose will result in a high tumor …