Ischemic insult to the myocardium is associated with cardiomyocyte apoptosis. Because
apoptotic cell death is characterized by phosphatidylserine externalization on cell …

Annexin A5 is a phospholipid binding protein with high affinity for phosphatidyl-serine, which
is externalized by cells undergoing programmed cell death. An increased programmed cell …

There is increasing evidence that cell death after myocardial ischemia and reperfusion may
begin as apoptosis rather than necrosis. To determine the time course, location, and extent …

Purpose 99m Tc-annexin V (ANX) allows scintigraphic detection of apoptotic cells via
specific binding to exposed phosphatidylserine. In myocardial infarction, apoptosis of …

99mTc-Annexin-V imaging has been proved to be feasible to detect phosphatidylserine,
which externalizes on the outer cell membrane early in the process of apoptosis. To …

Abstract Objective: Annexins are Ca2+-dependent phospholipid binding proteins.
Externalized annexin A5 has been recently suggested to have a proapoptotic effect. Our aim …

One of the earliest events in programmed cell death is the externalization of
phosphatidylserine, a membrane phospholipid normally restricted to the inner leaflet of the …

Medicine, is the difference in the mechanism of localization of the radiopharmaceutical
annexin A5, compared with that of antimyosin or pyrophosphate (2, 3). Both antimyosin and …

Apoptosis, an active process of cell self-destruction, is associated with myocardial ischemia.
The redistribution of phosphatidylserine (PS) from the inner to the outer leaflet of the cell …

With the use of markers of sarcolemmal membrane permeability, cardiomyocyte models of
ischemic injury have primarily addressed necrotic death during ischemia. In the present …