L-FBPA showed higher selectivity for L-type amino acid transporter 1: in vitro cellular uptake analysis compared to L-Methionine.

H Ikeda, T Watabe, S Nagamori, Y Tanaka… - 2016 - Soc Nuclear Med
1167 Objectives L isomeric form of 4-borono-2-(18) F-fluoro-phenylalanine (L-FBPA) has
been reported to show high uptake in the malignant tumors and less physiological …

Evaluation of the amino acid transporter: comparison study between FBPA and BPA in vitro.

H Ikeda, T Watabe, S Nagamori, Y Tanaka… - 2015 - Soc Nuclear Med
1112 Objectives 4-borono-phenylalanine (BPA) has been used as carrier of 10 B into the
tumor for boron neutron capture therapy. The PET tracer 18 F-FBPA is used to estimate …

(18) F-FBPA as a tumor specific tracer of L-type amino acid transporter 1 (LAT1): PET evaluation in tumor and inflammation compared to (18) F-FDG and (11) C …

T Watabe, J Hatazawa - Hellenic Journal of Nuclear Medicine, 2015 - europepmc.org
Objective (18) F-FDG-PET is used worldwide for oncology patients. However, we sometimes
encounter false positive cases of (18) F-FDG PET, such as moderate uptake in the …

18F-FBPA as a tumor-specific probe of L-type amino acid transporter 1 (LAT1): a comparison study with 18F-FDG and 11C-Methionine PET

T Watabe, H Ikeda, S Nagamori… - European journal of …, 2017 - Springer
Purpose The purpose of this study was to evaluate the usefulness of L-4-borono-2-18 F-
fluoro-phenylalanine (18 F-FBPA) as a tumor-specific probe, in comparison to 18 F-FDG and …

Predominant contribution of L-type amino acid transporter to 4-borono-2-18F-fluoro-phenylalanine uptake in human glioblastoma cells

M Yoshimoto, H Kurihara, N Honda, K Kawai… - Nuclear medicine and …, 2013 - Elsevier
INTRODUCTION: 4-Borono-2-18F-fluoro-phenylalanine (18F-FBPA) has been used to
anticipate the therapeutic effects of boron neutron capture therapy (BNCT) with 4-borono-L …

Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET

P Wiriyasermkul, S Nagamori… - Journal of Nuclear …, 2012 - Soc Nuclear Med
l-3-18F-α-methyl tyrosine (18F-FAMT) has been developed as a PET radiotracer for tumor
imaging. Clinical studies have demonstrated the usefulness of 18F-FAMT PET for the …

Specific transport of 3‐fluoro‐l‐α‐methyl‐tyrosine by LAT1 explains its specificity to malignant tumors in imaging

L Wei, H Tominaga, R Ohgaki, P Wiriyasermkul… - Cancer …, 2016 - Wiley Online Library
3‐18F‐l‐α‐methyl‐tyrosine ([18F] FAMT), a PET probe for tumor imaging, has advantages of
high cancer‐specificity and lower physiologic background. FAMT‐PET has been proved …

[18F] AA-7: A novel PET tracer for imaging L-type amino acid transporter 1 (LAT1)-positive tumors

S Nozaki, Y Nakatani, Y Sasano, K Yamamoto… - 2015 - Soc Nuclear Med
1184 Objectives [18 F] FDG PET is associated with false-positive findings due to rebound
inflammation after chemotherapy and radiotherapy in clinical oncology. Radiolabeled amino …

Biological evaluation of 3-[18F]fluoro-α-methyl-d-tyrosine (d-[18F]FAMT) as a novel amino acid tracer for positron emission tomography

Y Ohshima, H Hanaoka, H Tominaga, Y Kanai… - Annals of nuclear …, 2013 - Springer
Abstract Objective 3-[18 F] Fluoro-α-methyl-l-tyrosine (l-[18 F] FAMT) is a useful amino acid
tracer for positron emission tomography (PET) imaging of malignant tumors. Because d …

L-type amino acid transporters LAT1 and LAT4 in cancer: uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro …

C Haase, R Bergmann, F Fuechtner… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Expression of system L amino acid transporters (LAT) is strongly increased in many types of
tumor cells. The purpose of this study was to demonstrate that 18F-labeled amino acids, for …