Radionuclide imaging monitoring hypoxia tumor microenvironment improved homologous targeting probe for enhancing photodynamic therapy

H Fang, Y Gai, S Wang, Y Zhang, X Lan - 2020 - Soc Nuclear Med
1058 Objectives: Photodynamic therapy (PDT) efficacy is often limited by the hypoxia of
tumor microenvironment, while perfluorocarbon (PFTBA) has extremely high oxygen …

Glutathione depletion and dual-model oxygen balance disruption for photodynamic therapy enhancement

W Li, J Yong, Y Xu, Y Wang, Y Zhang, H Ren… - Colloids and Surfaces B …, 2019 - Elsevier
Photodynamic therapy (PDT) is a prospective approach to cure tumor diseases. However,
tumor micro-environment is notably characterized with severe hypoxia and high expression …

Oxygen self-sufficient fluorinated polypeptide nanoparticles for NIR imaging-guided enhanced photodynamic therapy

P Yuan, Z Ruan, W Jiang, L Liu, J Dou, T Li… - Journal of Materials …, 2018 - pubs.rsc.org
A major hindrance for photodynamic therapy (PDT) to achieve higher efficiency is the
hypoxia environment in the tumor area and the PDT-induced continuous consumption of …

Mitochondria-targeting oxygen-sufficient perfluorocarbon nanoparticles for imaging-guided tumor phototherapy

S Chen, B Huang, W Pei, L Wang, Y Xu… - International journal of …, 2020 - Taylor & Francis
Background Although photothermal therapy (PTT) and photodynamics therapy (PDT) have
both made excellent progress in tumor therapy, the effectiveness of using PTT or PDT alone …

IR780 Conjugated TSPO-binding Ligand Loaded pH-sensitive Nanoplatform for Effective TSPO Targeted Photodynamic Therapy

M Jeon, SH Lee, W Lee, BC Lee, SE Kim, HJ Im - 2021 - Soc Nuclear Med
1272 Purpose: Translocator protein (TSPO) is one of the emerging cancer biomarkers and
has been shown to be associated with poor prognosis in a variety of malignancies …

Conquering the hypoxia limitation for photodynamic therapy

Y Wan, LH Fu, C Li, J Lin, P Huang - Advanced Materials, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

Perfluorocarbon-based O 2 nanocarrier for efficient photodynamic therapy

H Hu, X Yan, H Wang, J Tanaka, M Wang… - Journal of materials …, 2019 - pubs.rsc.org
Tumor hypoxia is considered as one of the major factors that limit the efficiency of
photodynamic therapy (PDT), in which oxygen (O2) is needed to generate singlet oxygen …

[HTML][HTML] Strategies to improve photodynamic therapy efficacy by relieving the tumor hypoxia environment

Z Shen, Q Ma, X Zhou, G Zhang, G Hao, Y Sun… - NPG Asia …, 2021 - nature.com
Photodynamic therapy (PDT) is an emerging technology for tumor treatment in which
photosensitizer (PS)-mediated light irradiation reduces oxygen, producing high levels of …

Light-controlled oxygen production and collection for sustainable photodynamic therapy in tumor hypoxia

H Wang, Y Guo, C Wang, X Jiang, H Liu, A Yuan, J Yan… - Biomaterials, 2021 - Elsevier
Hypoxia exists in most malignant tumors and often contributes to therapy resistance,
especially for aerobic treatments such as photodynamic therapy (PDT) and radiotherapy …

Perfluorocarbon‐loaded and redox‐activatable photosensitizing agent with oxygen supply for enhancement of fluorescence/photoacoustic imaging guided tumor …

DR Hu, L Zhong, MY Wang, HH Li, Y Qu… - Advanced Functional …, 2019 - Wiley Online Library
The wide clinical application of photodynamic therapy (PDT) is hampered by poor water
solubility, low tumor selectivity, and nonspecific activation of photosensitizers, as well as …