Imaging of apoptosis: the need to distinguish tracer uptake rate from regional contribution of blood flow

HJ Machulla - Journal of Nuclear Medicine, 2015 - Soc Nuclear Med
In oncology, PET is known to contribute substantially to localization of tumors and
metastases and to control of therapy. One particularly attractive application is the assay of …

131I-labeled peptides as caspase substrates for apoptosis imaging

C Bauer, U Bauder-Wuest, W Mier… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Nonivasive assessment of programmed cell death is currently an attractive research topic for
the follow-up of tumor therapy and myocardial infarction. Apoptosis imaging with 99mTc …

Detection of tumor cell apoptosis by PET: Comparison of [18F] C-SNAT,[99mTc] HYNIC-Annexin V and [18F] ML-10

T Witney, A Hoehne, O Ilovich, M Namavari, B Shen… - 2014 - Soc Nuclear Med
1377 Objectives It has been shown recently that [18 F] C-SNAT can be used to detect early
response to therapy in tumors by PET via a mechanism of caspase 3-triggered cyclization …

Methodological aspects and applications of in vivo imaging of apoptosis in oncology: an illustrative review

MS Kartachova, M Verheij, CA Hoefnagel… - Current Medical …, 2005 - ingentaconnect.com
In vivo monitoring of apoptosis during anticancer therapy has attracted intense research
interest as a potential assay to predict treatment outcome. From all apoptosis-detecting …

Recent advances in apoptosis imaging using radionuclide-labeled tracers

S An, S Song, G Huang - … Journal of Radiation Medicine and Nuclear …, 2015 - inis.iaea.org
[en] Apoptosis or programmed cell death is an important form of cell death. Apoptosis is
involved in numerous human pathological conditions, such as neurodegenerative diseases …

Molecular imaging of cell death

M De Saint-Hubert, K Prinsen, L Mortelmans… - Methods, 2009 - Elsevier
Apoptosis (programmed cell death) and necrosis (uncontrolled cell death) are two distinct
processes of cell death that have been described. Non-invasive molecular imaging of these …

[HTML][HTML] Interest and limits of [18F] ML-10 PET imaging for early detection of response to conventional chemotherapy

E Jouberton, S Schmitt, A Maisonial-Besset… - Frontiers in …, 2021 - frontiersin.org
One of the current challenges in oncology is to develop imaging tools to early detect the
response to conventional chemotherapy and adjust treatment strategies when necessary …

In vivo detection of apoptosis

FG Blankenberg - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
After several decades of debate, it is now widely acknowledged that apoptosis, also known
as programmed cell death, is central to homoeostasis and normal development and …

Apoptosis imaging probe predicts early chemotherapy response in preclinical models: a comparative study with 18F-FDG PET

S Song, C Xiong, W Lu, G Ku, G Huang… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Previously, we reported a small-molecular-weight peptide, single amino acid chelae
(99mTc)-conjugated phosphatidylserine-binding peptide (SAAC (99mTc)-PSBP-6), with high …

Monitoring of treatment-induced apoptosis in oncology with PET and SPECT

FG Blankenberg - Current pharmaceutical design, 2008 - ingentaconnect.com
The early assessment of a solid tumor's response to conventional or new drug therapy to
complement or replace current RECIST (or other clinical) criteria remains an elusive goal …