The purpose of this study was to develop a bifunctional iron oxide (IO) nanoparticle probe for
PET and MRI scans of tumor integrin αvβ3 expression. Methods: Polyaspartic acid (PASP) …

A Mn3O4 nanoparticle (NP)-based dual-modality probe has been developed for tumor
positron emission tomography (PET)/magnetic resonance (MR) imaging. The dual-modality …

Multifunctional and water-soluble superparamagnetic iron oxide (SPIO) nanocarriers were
developed for targeted drug delivery and positron emission tomography/magnetic …

A key challenge in developing nanoplatform-based molecular imaging is to achieve an
optimal pharmacokinetic profile to allow sufficient targeting and to avoid rapid clearance by …

Combination of complementary imaging techniques, like hybrid PET/MRI, allows protocols to
be developed that exploit the best features of both. In order to get the best of these …

A novel nanoparticle-based dual-modality positron emission tomograph/magnetic
resonance imaging (PET/MRI) contrast agent was developed. The probe consisted of a …

The αv-integrins, cell adhesion molecules that are highly expressed on activated endothelial
cells and tumor cells but not on dormant endothelial cells or normal cells, present an …

PET with 18F-labeled arginine-glycine-aspartic acid (RGD) peptides can visualize and
quantify ανβ3 integrin expression in patients, but radiolabeling is complex and image …

Integrin αvβ3 plays a critical role in tumor-induced angiogenesis and metastasis and has
become a promising diagnostic indicator and therapeutic target for various solid tumors …

A new class of nanoparticle-based dual-modality positron emission tomography/magnetic
resonance imaging (PET/MRI) contrast agents has been developed. The probe consists of a …