Three Tc-99m-labeled neutral 1, 2-dfthia-5, 8-dlazacycIodecane (BAT) chelates that are
capable of crossingthe blood-brainbarrier (BBB) were preparedandeval uated …

The structure-activity relationship in a series of analogues of 99mTc-bicisate (99mTc-N, N'-1,
2-ethylenediylbis-L-cysteine diethyl ester dihydrochloride, RP-217) is described using in …

A newligand (N-pipendinylethyl-DADT, 5) hasbeenpreparedwhichformstwocomplexes
with@ Tcwhen stannouschloride is used as a reducingagent for@ TcJpertechnetate …

In developing new brain perfusion imaging agents, three types of neutral and lipid-soluble
technetium 99m complexes have been reported: 99m Tc-ethylene cysteinate dimer, 99m Tc …

0 Silica gel-acetone. 6Silica gel-acetone: dichloromethane (1: 2). c Column: reverse-phase
Hamilton PRP-1. Solvent: acetonitrile-3, 3-dimethylglutarate buffer pH 7.0, 0.1 mM (85: 15) …

T, he search for suitable agents for use as indicators of regional cerebral perfusion has
yielded, in the past few years, the promising agents N, N, N'-trimethyl-N-[2-hydroxy-3-methyl …

Bisaminoethanethiol (BAT) ligands with various gem-dimethyl and amide groups were
prepared, and the corresponding neutral Tc-99m complexes were prepared and evaluated …

In developing new brain perfusion imaging agents for single photon emission computed
tomography (SPECT), five 99mTc-labeled neutral bis (aminoethanethiol)(BAT) derivatives …

The following ligands as the tri-HCl salts were prepared in an analogous fashion to the
procedure for NEP-DADT (/): N-ethylpiperidinyl DADT (NEP-DADT, I, see Fig. 1); N-ethyl N …

Two 99m Tc complexes of (N-piperidinylethyl) hexamethyl diaminodithiol (NEP-DADT) have
shown high brain uptake in rodents and lower primates. One of these 99m Tc complexes …