Reproducibility of repeated measures of cholinergic terminal density using [18F](+)-4-fluorobenzyltrozamicol and PET in the rhesus monkey brain

HD Gage, ML Voytko, RLE Ehrenkaufer… - Journal of Nuclear …, 2000 - Soc Nuclear Med
[18F](+)-4-fluorobenzyltrozamicol (FBT), which selectively binds to the vesicular
acetylcholine transporter in the presynaptic cholinergic neuron, has previously been shown …

Imaging of cholinergic terminals using the radiotracer [18F](+)‐4‐fluorobenzyltrozamicol: In vitro binding studies and positron emission tomography studies in …

RH Mach, ML Voytko, RLE Ehrenkaufer, MA Nader… - Synapse, 1997 - Wiley Online Library
The goal of the present set of studies was to characterize the in vitro binding properties and
in vivo tissue kinetics for the vesicular acetylcholine transporter (VAcChT) …

Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F] F-A85380

AS Kimes, SI Chefer, JA Matochik, CS Contoreggi… - Neuroimage, 2008 - Elsevier
Quantitative analysis of most positron emission tomography (PET) data requires arterial
blood sampling and dynamic scanning when the radioligand is administered as a bolus …

PET imaging of the vesicular acetylcholine transporter

M Petrou, R Koeppe, P Scott, N Bohnen, M Kilbourn… - 2012 - Soc Nuclear Med
290 Objectives 18 F-FEOBV (fluoroethoxybenzovesamicol) is a vesamicol analogue which
selectively binds to the vesicular acetylcholine transporter and has been used in preclinical …

Distribution of the 5-HT1A receptor antagonist [18F]FPWAY in blood and brain of the rat with and without isoflurane anesthesia

J Tokugawa, L Ravasi, T Nakayama, L Lang… - European journal of …, 2007 - Springer
Purpose To determine whether brain and plasma equilibrium of a proposed PET tracer for 5-
HT 1A,[18 F] FPWAY, can be achieved in a sufficiently short time for practical use of the brain …

[HTML][HTML] Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase …

MJ Parent, M Cyr, A Aliaga, A Kostikov… - EJNMMI research, 2013 - Springer
Abstract Background Fluorine-18 fluoroethoxybenzovesamicol ([18 F] FEOBV) is a
radioligand for the selective imaging of the vesicular acetylcholine transporter with positron …

PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements

SS Zoghbi, HU Shetty, M Ichise, M Fujita… - Journal of Nuclear …, 2006 - Soc Nuclear Med
18F-2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-fluoroethyl) nortropane (18F-FECNT), a
PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters …

Quantification of dopamine transporter density with [18F] FECNT PET in healthy humans

JA Nye, JR Votaw, JD Bremner, MR Davis… - Nuclear medicine and …, 2014 - Elsevier
Abstract Introduction Fluorine-18 labeled 2β-carbomethoxy-3β-(4-chlorophenyl)-8-(2-
fluoroethyl) nortropane ([18 F] FECNT) binds reversibly to the dopamine transporter (DAT) …

First-in-human PET quantification study of cerebral α4β2* nicotinic acetylcholine receptors using the novel specific radioligand (−)-[18F] Flubatine

O Sabri, GA Becker, PM Meyer, S Hesse, S Wilke… - Neuroimage, 2015 - Elsevier
Abstract α4β2* nicotinic receptors (α4β2* nAChRs) could provide a biomarker in
neuropsychiatric disorders (eg, Alzheimer's and Parkinson's diseases, depressive disorders …

Quantification of Cerebral Nicotinic Acetylcholine Receptors by PET Using 2-[18F]Fluoro-A-85380 and the Multiinjection Approach

JD Gallezot, MA Bottlaender… - Journal of Cerebral …, 2008 - journals.sagepub.com
The multiinjection approach was used to study in vivo interactions between α4β2* nicotinic
acetylcholine receptors and 2-[18F] fluoro-A-85380 in baboons. The ligand kinetics was …