Abnormalities in myocardial L-type Ca2+ channel abundance and function have been
described in cardiac hypertrophy and failure. In vivo quantification of the density of these …

The in vivo determination of the density of dihydropyridine (DHP) binding sites will allow the
assessment of pathophysiological changes associated with heart disease. The calcium …

Ca2+ channels play a key role in the basic working of the heart. There is one particular type
of Ca2+ channel in cardiac cells (L-type) whose gating is affected in different ways by β …

An increase in the number of voltage dependent calcium channels has been implicated in
the overload of calcium found in cardiac tissue of the cardiomyopathic hamster. We …

Publisher Summary Drugs that regulate Ca 2+ influx via voltage-gated Ca 2+ channels are
called calcium antagonists or calcium-channel blockers. Phenylalkylamines …

Study objective—The aim was to determine if the adaptational process of the cardiac
calcium channel to pressure overload observed in rat heart also occurs in species …

The selectivity of action of the clinically available calcium channel antagonists depends on a
number of factors: 1) Mode of calcium mobilization—intracellular and extracellular sources …

The [3 H] nitrendipine binding activity of sarcolemmal fragments isolated from aerobically
perfused or ischemic rat hearts was studied. After 90 min aerobic perfusion, two populations …

Objective: We investigated the effect of ischemia on cardiac dihydropyridine receptors,
which correspond to L-type sarcolemmal calcium channels. Methods: Isolated working rat …

Abstract The 1, 4-dihydropyridine receptor associated with L-type Ca 2+ channels was
purified about 1700-fold from porcine cardiac sarcolemmal membranes using a simple and …