1564 Objectives The optimal dosage ratio of antibody to effector in pretargeting is
proportional to the ratio of their maximum percent tumor accumulations (MPTAs). As a …

Our previous studies have indicated that the optimal dosage ratio of pretargeting antibody to
effector is proportional to their maximum percent tumour accumulations (MPTAs). This study …

1680 Objectives: MORF pretargeting requires both a MORF conjugated antitumor antibody
and a radiolabeled cMORF effector. This complexity necessitates investigations into the …

In treating tumors by pretargeting, the antitumor antibody and the cytotoxic effector (eg,
toxins and radioactivity) are separately administered. Therefore, pretargeting is more …

The limited success of the sole use of monoclonal antibodies for cancer detection and
treatment has led to the development of multistep methods using antibodies in conjunction …

Pretargeting is often used as a tumor targeting strategy that provides much higher tumor to
non-tumor ratios than direct-targeting using radiolabeled antibody. Due to the multiple …

Pharmacokinetic Comparison of Direct Antibody Targeting with Pretargeting Protocols Based
on Streptavidin-Biotin Binding Page 1 body, to bind to the tissues expressing the antigen, and …

Many questions regardingthe opti mal dosing schedule, timing, molecu larweight, valency,
affinityconstants, specific activity, rates of metabolism and antigen modulation in pretarget …

This laboratory is exploring the use of morpholinos (MORFs), synthetic DNA analogues, for
nuclear medicine applications, including pretargeting. The anti-CEA antibody MN14 was …

Pre-clinical studies of three step pretargeting of an anti-hapten mAb were done in BALB/c
mice with KHJJ mouse adenocarcinoma. An 80% reduction in whole body radiation burden …