[HTML][HTML] 99mTc-labelled anti-CD11b SPECT/CT imaging allows detection of plaque destabilization tightly linked to inflammation

G Liu, Y Hu, J Xiao, X Li, Y Li, H Tan, Y Zhao… - Scientific reports, 2016 - nature.com
It remains challenging to predict the risk of rupture for a specific atherosclerotic plaque
timely, a thrombotic trigger tightly linked to inflammation. CD11b, is a biomarker abundant on …

Towards non-invasive imaging of vulnerable atherosclerotic plaques by targeting co-stimulatory molecules

A Müller, L Mu, R Meletta, K Beck, Z Rancic… - International journal of …, 2014 - Elsevier
Background Myocardial infarction and stroke are the life-threatening consequences after
plaque rupture in coronary or carotid arteries. Positron emission tomography employing [18 …

[HTML][HTML] CD40-targeting magnetic nanoparticles for MRI/optical dual-modality molecular imaging of vulnerable atherosclerotic plaques

Q Wu, W Pan, G Wu, F Wu, Y Guo, X Zhang - Atherosclerosis, 2023 - Elsevier
Background and aims Acute coronary syndrome caused by vulnerable plaque rupture or
erosion is a leading cause of death worldwide. CD40 has been reported to be highly …

[HTML][HTML] αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice

D Vancraeynest, V Roelants, C Bouzin, FX Hanin… - EJNMMI research, 2016 - Springer
Background α V β 3-integrin is expressed by activated endothelial cells and macrophages in
atherosclerotic plaques and may represent a valuable marker of high-risk plaques. We …

CD11b-Based Pre-Targeted SPECT/CT Imaging Allows for the Detection of Inflammation in Aortic Aneurysm

X Zhou, K Zhu, Y Zhang, Y Ming, D Shi… - Journal of …, 2022 - Taylor & Francis
Purpose To investigate the feasibility of a pre-targeted imaging strategy based on the
cycloaddition between 1, 2, 4, 5-terazine (Tz) and trans-cyclooctene (TCO) for evaluating …

[HTML][HTML] Immuno-PET Imaging of Atherosclerotic Plaques with [89Zr]Zr-Anti-CD40 mAb—Proof of Concept

K Poels, M Schreurs, M Jansen, DJ Vugts… - Biology, 2022 - mdpi.com
Simple Summary Atherosclerosis is characterized by gradual plaque build-up in the middle
and large arteries and is the major cause of cardiovascular disease. Determining which …

CC chemokine receptor 5 targeted nanoparticles imaging the progression and regression of atherosclerosis using positron emission tomography/computed …

L Detering, A Abdilla, HP Luehmann… - Molecular …, 2021 - ACS Publications
Chemokines and chemokine receptors play an important role in the initiation and
progression of atherosclerosis by mediating the trafficking of inflammatory cells. Chemokine …

[HTML][HTML] Imaging of inflammatory cellular protagonists in human atherosclerosis: a dual-isotope SPECT approach

HE Barrett, EJ Meester, K van Gaalen… - European Journal of …, 2020 - Springer
Purpose Atherosclerotic plaque development and progression signifies a complex
inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using …

Imaging monocytes with iron oxide nanoparticles targeted towards the monocyte integrin MAC‐1 (CD11b/CD18) does not result in improved atherosclerotic plaque …

C von Zur Muhlen, A Fink‐Petri… - Contrast media & …, 2010 - Wiley Online Library
Imaging of macrophages with superparamagnetic iron oxide particles (SPIO) has been
performed to improve detection of atherosclerotic plaque inflammation in human and mouse …

CD93 in macrophages: A novel target for atherosclerotic plaque imaging?

C Su, Y Han, B Qu, C Zhang, T Liang… - Journal of Cellular …, 2022 - Wiley Online Library
Noninvasive imaging atherosclerotic (AS) plaque is of great importance for early diagnosis.
Recently, CD93 in MΦ was linked to atherosclerosis development. Herein, we have …