Coronavirus disease 2019 (COVID-19) can cause life-threatening lung inflammation that is
thought to be mediated by neutrophils. The aim of the present work was to evaluate a novel …

A growing body of evidence indicates that neutrophil elastase (NE) is involved in the
pathogenesis of respiratory infectious diseases, such as severe acute respiratory syndrome …

Background Many arguments suggest that neutrophils could play a prominent role in COVID‐
19. However, the role of key components of neutrophil innate immunity in severe forms of …

Pulmonary fibrosis, severe alveolitis, and the inability to restore alveolar epithelial
architecture are primary causes of respiratory failure in fatal COVID-19 cases. However, the …

Neutrophilia and an elevated neutrophil: lymphocyte ratio are both characteristic features of
severe COVID-19 infection. However, functional neutrophil responses have been poorly …

Background Severe acute respiratory syndrome caused by a novel coronavirus 2 (SARS-
CoV-2) has infected more than 18 million people worldwide. The activation of endothelial …

An excess formation of neutrophil extracellular traps (NETs), previously shown to be strongly
associated with cytokine storm and acute respiratory distress syndrome (ARDS) with …

Objectives Critical illness in COVID-19 is attributed to an exaggerated host immune
response. Since neutrophils are the major component of innate immunity, we hypothesize …

Background COVID-19 is characterized by severe acute lung injury, which is associated with
neutrophil infiltration and the release of neutrophil extracellular traps (NETs). COVID-19 …

The novel coronavirus SARS-CoV-2 causes COVID-19, a highly pathogenic viral infection
threatening millions. The majority of the individuals infected are asymptomatic or mildly …