Derivation of the plasma time–activity curve in murine small-animal PET studies is a
challenging task when tracers that are sequestered by the myocardium are used, because …

We present and validate a method to obtain an input function from dynamic image data and
0 or 1 blood sample for small-animal 18F-FDG PET studies. The method accounts for …

For cardiovascular research on rodents, small-animal PET has limitations because of the
inherent spatial resolution of the system and because of cardiac motion. A factor analysis …

18F-FDG kinetics are quantified by a 2-tissue-compartment model. The routine use of
dynamic PET is limited because of this modality's 1-h acquisition time. We evaluated …

Purpose Accurate determination of the plasma input function (IF) is essential for absolute
quantification of physiological parameters in positron emission tomography (PET). However …

A modified short dynamic protocol was defined and evaluated to predict kinetic parameters
of 18F-FDG metabolism from a dynamic data acquisition. Methods: The evaluation included …

We describe and validate a hybrid image and blood sampling (HIBS) method to derive the
input function for quantification of microPET mice data. The HIBS algorithm derives the peak …

The aim of this study was to explore the feasibility of determining parameters of
cardiovascular function in mice noninvasively by high-temporal-resolution imaging with a …

Objective A method of defining the image-derived input function (IDIF) was introduced and
evaluated for the quantification of the regional cerebral metabolic rate of glucose in PET …

The utilization of image-derived input functions is becoming common in quantitative PET
studies of the heart. Consequently, imaging protocols must be designed to sample both …