Nondisplaceable binding is a potential confounding factor in 11C-PBR28 translocator protein PET studies
GL Laurell, P Plavén-Sigray, A Jucaite… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The PET ligand 11C-PBR28 (N-((2-(methoxy-11C)-phenyl) methyl)-N-(6-phenoxy-3-
pyridinyl) acetamide) binds to the 18-kDa translocator protein (TSPO), a biomarker of glia. In …
pyridinyl) acetamide) binds to the 18-kDa translocator protein (TSPO), a biomarker of glia. In …
[HTML][HTML] Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176 …
Translocator protein (TSPO) is a biomarker for detecting neuroinflammation by PET. 11 C-
(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility …
(R)-PK11195 has been used to image TSPO since the 1980s. Here, we compared the utility …
Determination of [11C]PBR28 Binding Potential in vivo: A First Human TSPO Blocking Study
Positron emission tomography (PET) targeting the 18 kDa translocator protein (TSPO) is
used to quantify neuroinflammation. Translocator protein is expressed throughout the brain …
used to quantify neuroinflammation. Translocator protein is expressed throughout the brain …
Comparison of standardized uptake values with volume of distribution for quantitation of [11C] PBR28 brain uptake
KK Yoder, PR Territo, GD Hutchins, J Hannestad… - Nuclear medicine and …, 2015 - Elsevier
Abstract Introduction [11 C] PBR28 is a high-affinity ligand for the Translocator Protein 18
kDa (TSPO), which is considered to be a marker for microglial activation. Volume of …
kDa (TSPO), which is considered to be a marker for microglial activation. Volume of …
Mixed-affinity binding in humans with 18-kDa translocator protein ligands
11C-PBR28 PET can detect the 18-kDa translocator protein (TSPO) expressed within
macrophages. However, quantitative evaluation of the signal in brain tissue from donors with …
macrophages. However, quantitative evaluation of the signal in brain tissue from donors with …
Kinetic modelling of [11C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis
M Veronese, T Reis Marques… - Journal of Cerebral …, 2018 - journals.sagepub.com
The 18 kDa translocator protein (TSPO) is a marker of microglia activation in the central
nervous system and represents the main target of radiotracers for the in vivo quantification of …
nervous system and represents the main target of radiotracers for the in vivo quantification of …
Non-invasive estimation of [11C] PBR28 binding potential
Abstract [11 C] PBR28 is a PET radioligand used to estimate densities of the 18 kDa
translocator protein (TSPO) in vivo. Since there is no suitable reference region, arterial blood …
translocator protein (TSPO) in vivo. Since there is no suitable reference region, arterial blood …
Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binding to translocator protein
CH Lyoo, M Ikawa, JS Liow, SS Zoghbi… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Alzheimer disease (AD) is associated with an increase in the brain of the 18-kDa
translocator protein (TSPO), which is overexpressed in activated microglia and reactive …
translocator protein (TSPO), which is overexpressed in activated microglia and reactive …
[CITATION][C] Are prescribed benzodiazepines likely to affect the availability of the 18 kDa translocator protein (TSPO) in PET studies?
PET ligands such as [11C] PK11195 and [11C] PBR28, target the translocator protein
(TSPO), originally designated the Peripheral Benzodiazepine Receptor (PBR; …
(TSPO), originally designated the Peripheral Benzodiazepine Receptor (PBR; …
11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain
M Ikawa, TG Lohith, S Shrestha, S Telu… - Journal of Nuclear …, 2017 - Soc Nuclear Med
For PET imaging of 18-kDa translocator protein (TSPO), a biomarker of neuroinflammation,
most second-generation radioligands are sensitive to the single nucleotide polymorphism …
most second-generation radioligands are sensitive to the single nucleotide polymorphism …