Synthesis and characterization of [18F] mG2P026 as a high contrast PET imaging ligand for metabotropic glutamate receptor 2

G Yuan, M Dhaynaut, N Guehl, SH Moon, X Qu… - 2021 - Soc Nuclear Med
11 Objectives: Metabotropic glutamate receptor 2 (mGluR2) is presynaptically expressed in
neurons and astrocytes where it modulates the synaptic transmission and participates in …

Synthesis and characterization of [18F] mG2P018 as the first efficient 18F-labeled PET imaging ligand for metabotropic glutamate receptor 2

G Yuan, C Pan, X Qu, AL Brownell - 2020 - Soc Nuclear Med
266 Objectives: Metabotropic glutamate receptor 2 (mGluR2) has been implicated in various
psychiatric and neurological disorders. Development of specific PET imaging ligand is …

Development of [11C] mG3N001 as a PET imaging ligand for metabotropic glutamate receptor 3 (mGluR3)

J Wang, C Wang, G El Fakhri, P Caravan, Z Zhang… - 2020 - Soc Nuclear Med
1041 Objectives: Metabotropic glutamate receptors (mGluRs) have emerged as new drug
targets with great potential for treatment of a range of central nervous system (CNS) …

[HTML][HTML] Synthesis, radiolabelling and in vitro and in vivo evaluation of a novel fluorinated ABP688 derivative for the PET imaging of metabotropic glutamate receptor …

SM Sephton, P Dennler, DS Leutwiler… - American Journal of …, 2012 - ncbi.nlm.nih.gov
Abstract (E)-3-(Pyridin-2-ylethynyl) cyclohex-2-enone O-(2-(3-18 F-fluoropropoxy) ethyl)
oxime ([18 F]-PSS223) was evaluated in vitro and in vivo to establish its potential as a PET …

Development of [11C] mG2P001 as an efficient PET imaging ligand for metabotropic glutamate 2 receptor

B Zheng, G Yuan, R Neelamegam, A Zhu, JK Choi… - 2018 - Soc Nuclear Med
1024 Objectives: Metabotropic glutamate 2 receptor (mGluR2) belongs to the group II
metabotropic glutamate receptors. Activation of mGluR2 decreases the release of excitatory …

Radiosynthesis and evaluation of [11C] YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1

K Yanamoto, F Konno, C Odawara, T Yamasaki… - Nuclear medicine and …, 2010 - Elsevier
INTRODUCTION: Developing positron emission tomography (PET) ligands for imaging
metabotropic glutamate receptor type 1 (mGluR1) is important for studying its role in the …

Radiation dosimetry and human brain imaging of [18F] SP203: A PET radioligand for the metabotropic glutamate mGluR5 receptor

AK Brown, F Simeon, JS Liow, S Zoghbi, Y Kimara… - NeuroImage, 2008 - Elsevier
Methods Three whole body monkey scans were performed after injection of [18 F] SP203
(269±109 MBq) and two scans after injection of [18 F] SP203B (78.1 and 48.8 MBq). Three …

Synthesis and evaluation of a F-18 labeled tricyclic thiazolopyrazole derivative for imaging of metabotropic glutamate receptor 4 (mGluR4)

J Wang, T Shoup, X Qu, HJ Kang, G El Fakhri, Z Zhang… - 2020 - Soc Nuclear Med
1031 Objectives: The development of mGluR4 positive allosteric modulators (PAMs) has
gained great interest due to the potential benefit in treating numerous neuronal diseases …

Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM

T Yamasaki, M Fujinaga, J Maeda, K Kawamura… - European journal of …, 2012 - Springer
Purpose In this study, we evaluate the utility of 4-[18 F] fluoro-N-[4-[6-(isopropylamino)
pyrimidin-4-yl]-1, 3-thiazol-2-yl]-N-methylbenzamide ([18 F] FITM) as a positron emission …

Synthesis and Evaluation in Monkey of [18F]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([18F]FIMX): A Promising Radioligand …

R Xu, P Zanotti-Fregonara, SS Zoghbi… - Journal of medicinal …, 2013 - ACS Publications
We sought to develop a PET radioligand that would be useful for imaging human brain
metabotropic subtype 1 receptors (mGluR1) in neuropsychiatric disorders and in drug …