Characterization of iodovinylmisonidazole as a marker for myocardial hypoxia.
GV Martin, JE Biskupiak, JH Caldwell… - Journal of Nuclear …, 1993 - europepmc.org
Misonidazole and related compounds are metabolically trapped in viable cells as a function
of reduced cellular pO2.[18F] fluoromisonidazole has been used to detect hypoxia in the …
of reduced cellular pO2.[18F] fluoromisonidazole has been used to detect hypoxia in the …
[PDF][PDF] Enhanced binding of the hypoxic cell marker [3H] fluoromisonidazole in ischemic myocardium
GV Martin, JH Caldwell, JS Rasey… - Journal of nuclear …, 1989 - Soc Nuclear Med
The 2-nitroimidazolefluoromisonidazoleis metabolicallytrappedin viablehypoxiccellsin
inverse proportion to P02. This attribute suggests that [18F] fluoromisonidazolemay be …
inverse proportion to P02. This attribute suggests that [18F] fluoromisonidazolemay be …
Nitroimidazoles for imaging hypoxic myocardium
HW Strauss, A Nunn, K Linder - Journal of Nuclear Cardiology, 1995 - Elsevier
A series of radiopharmaceuticals that incorporate nitroimidazole moieties have
beensynthesized to detect decreased local tissue pO2. In contrast to agents that localize in …
beensynthesized to detect decreased local tissue pO2. In contrast to agents that localize in …
Fluoromisonidazole. A metabolic marker of myocyte hypoxia.
GV Martin, MD Cerqueira, JH Caldwell… - Circulation …, 1990 - Am Heart Assoc
Fluoromisonidazole is metabolically trapped in viable hypoxic cells in vitro. This property is
the basis for the hypothesis that [18F] fluoromisonidazole can be used to detect hypoxic …
the basis for the hypothesis that [18F] fluoromisonidazole can be used to detect hypoxic …
[PDF][PDF] Myocardial kinetics of fluorine-18 misonidazole: a marker of hypoxic myocardium
ME Shelton, CS Dence, DR Hwang… - Journal of nuclear …, 1989 - Soc Nuclear Med
RESULTS Hemodynamics Heart rate, perfusion pressure, left ventricular devel o_ pressure,
flow, and dP/dt during the pre-interven tion equilibration period were similar in all hearts …
flow, and dP/dt during the pre-interven tion equilibration period were similar in all hearts …
The potential for myocardial imaging with hypoxia markers
AJ Sinusas - Seminars in nuclear medicine, 1999 - Elsevier
Direct “hot spot” imaging of myocardial tissue hypoxia is potentially of great clinical
importance because available noninvasive approaches for the detection of myocardial …
importance because available noninvasive approaches for the detection of myocardial …
Myocardial Kinetics of a Putative Hypoxic Tissue Marker, 99mTc-Labeled Nitroimidazole (BMS-181321), After Regional Ischemia and Reperfusion
CK Stone, T Mulnix, RJ Nickles, B Renstrom… - Circulation, 1995 - Am Heart Assoc
Background A new nitroimidazole complex, 99mTc-propylene amine oxime-1, 2-
nitroimidazole (BMS-181321), has been developed to allow the positive imaging of hypoxic …
nitroimidazole (BMS-181321), has been developed to allow the positive imaging of hypoxic …
In vivo delineation of myocardial hypoxia during coronary occlusion using fluorine-18 fluoromisonidazole and positron emission tomography: a potential approach for …
ME Shelton, CS Dence, DR Hwang, P Herrero… - Journal of the American …, 1990 - Elsevier
Previous studies have demonstrated that the positron-emitting fluorine-18 (18 F)-labeled
fluoromisonidazole is a specific tracer of myocardial hypoxia. Its fractional extraction Is …
fluoromisonidazole is a specific tracer of myocardial hypoxia. Its fractional extraction Is …
Characteristics of the binding of labeled fluoromisonidazole in cells in vitro
JS Rasey, NJ Nelson, L Chin, ML Evans… - Radiation …, 1990 - meridian.allenpress.com
Radiolabeled fluoromisonidazole (FMISO) is being investigated as an imaging agent for
hypoxia in tumors and nonmalignant tissues in myocardial infarct or stroke. In this study in …
hypoxia in tumors and nonmalignant tissues in myocardial infarct or stroke. In this study in …
Kinetics of a putative hypoxic tissue marker, technetium-99m-nitroimidazole (BMS181321), in normoxic, hypoxic, ischemic and stunned myocardium.
H Kusuoka, K Hashimoto, K Fukuchi… - Journal of nuclear …, 1994 - europepmc.org
Methods The kinetics of BMS181321 were evaluated in isolated perfused rat hearts.
Technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and a non-nitroimidazole …
Technetium-99m-hexamethylpropyleneamine oxime (HMPAO) and a non-nitroimidazole …