Anti-Ga chelate MAbs were raised by immunization of BALB/c mice with Ga-N, N'-[2-hydroxy-
5-(ethylene-f3-carboxy) benzyl] eth Recently, we demonstrated the feasibility of combining …

To improve tumor: tissue ratios in immunoscintigraphy, a three-step targeting method has
been developed. The reagents used were (a) a radioactive, low molecular weight chelate …

1 We recently demonstrated the feasibility of combining enhanced tumor-to-tissue contrast
and PET imaging for immunoscintigraphic tumor localization in pancreas and colon …

Purpose An accurate diagnosis of colorectal carcinoma (CRC) can assist physicians in
developing reasonable therapeutic regimens, thereby significantly improving the patient's …

Pretargeting techniques that are based on the sequential administrations of bispecific
antitumor/antimetal chelate antibodies (BS-MAbs), a blocker to saturate the anti-chelate …

Background 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG-PET) is
widely used in diagnostic cancer imaging. However, the use of 18 F-FDG in PET-based …

Radiolabeling monoclonal antibodies (mAbs) allows the evaluation of biodistribution of
constructs in vivo through gamma camera imaging and also permits quantitation of mAb …

Purpose Recombinant antibodies isolated from human antibody libraries have excellent
affinities and high target specificity. As full-length IgGs are cleared inadequately slowly from …

Platelet-derived growth factor receptor β (PDGFRβ) is a transmembrane tyrosine kinase
receptor involved, for example, in angiogenesis. Overexpression and excessive signaling of …

The recent advances in the production of engineered antibodies have facilitated the
development and application of tailored, target-specific antibodies. Positron emission …