Currently, there is no low-molecular-weight agent for imaging of the pulmonary circulation.
Adrenomedullin (AM) is a peptide predominantly cleared by the pulmonary circulation …

Previous studies showed that adrenomedullin (AM) could be a promising agent for
molecular imaging of the pulmonary circulation, with abundant specific binding sites at the …

INTRODUCTION: We have recently demonstrated the effectiveness of 99m-technetium
adrenomedullin (AM) as a new molecular lung imaging agent that could provide significant …

No test currently exists for molecular imaging of pulmonary arterial hypertension (PAH).
Adrenomedullin is a vasodilator peptide predominantly cleared by pulmonary endothelial …

Circulating adrenomedullin (AM) levels are elevated in several cardiovascular diseases,
including pulmonary vascular diseases causing pulmonary hypertension. To date the …

This phase I study (NCT01539889) evaluated the safety, efficacy, and dosing of PulmoBind
for molecular imaging of pulmonary circulation. PulmoBind is a ligand of the adrenomedullin …

This example was designed to evaluate the biodistribution, pharmacokinetics and
multiorgan clearance of AM in rats in vivo. Quantification of single-pass pulmonary kinetics …

Direct labeling of linear adrenomedullin (AM) with 99mTc ([99mTc] AM) displayed excellent
selectivity for imaging the pulmonary circulation system in dogs. Hence, we investigated this …

Introduction Adrenomedullin receptors are highly expressed in human alveolar capillaries
and provide a molecular target for imaging the integrity of pulmonary microcirculation. In this …

The biodistribution, pharmacokinetics and multi-organ clearance of the vasodilator peptide
AM (adrenomedullin) were evaluated in rats and its single-pass pulmonary clearance was …