603 Objectives: The aggregation of misfolded tau protein is a neuropathological hallmark of
Alzheimer's disease (AD) and other tauopathies. Tau accumulation follows stereotypical …

2233 Introduction: Alzheimer's disease (AD) is neuropathologically characterized by the
presence of tau neurofibrillary tangles and amyloid-β (Aβ) plaques. Tau spread patterns in …

Tau neurofibrillary tangles, a pathophysiological hallmark of Alzheimer's disease (AD),
exhibit a stereotypical spatiotemporal trajectory that is strongly correlated with disease …

Alzheimer's disease is associated with the cerebral accumulation of neurofibrillary tangles of
hyperphosphorylated tau protein. The progressive occurrence of tau aggregates in different …

Background Amyloid and tau proteins are known pathological signatures of Alzheimer's
disease. Tau in particular spreads in the brains following stereotypical spatiotemporal …

Purpose Alzheimer's disease (AD) studies revealed that abnormal deposition of tau spreads
in a specific spatial pattern, namely Braak stage. However, Braak staging is based on post …

Background: Alzheimer's disease involves widespread and progressive deposition of
misfolded protein tau (τ), first appearing in the entorhinal cortex, coagulating in longer …

Tau tangles are a pathological hallmark of Alzheimer's disease (AD) with strong correlations
existing between tau aggregation and cognitive decline. Studies in mouse models have …

One of the hallmarks of Alzheimer's disease (AD) is the accumulation and spread of toxic
aggregates of tau protein. The progression of AD tau pathology is thought to be highly …

Objective: To predict the spread of tau in vivo based on structural connectivity with
individualized epicenters of tau pathology. Background: Despite the fundamental …