Molecular imaging is indispensable for determining the fate and persistence of engrafted
stem cells. Standard strategies for transgene induction involve the use of viral vectors prone …

Rationale: Molecular imaging has proven to be a vital tool in the characterization of stem cell
behavior in vivo. However, the integration of reporter genes has typically relied on random …

The sequencing of entire genomes along with advances in genomic engineering has
ushered in exciting new opportunities for scientists to not only better understand biology but …

We report the cloning of a 12-year-old transgenic green fluorescent protein (GFP) monkey
by somatic cell nuclear transfer (SCNT) and base editing of the embryos, accompanied with …

Stem cell therapy offers exciting promise for treatment of ischemic heart disease. Recent
advances in molecular imaging techniques now allow investigators to monitor cell fate …

One major challenge in stem cell therapy is to longitudinally track cell fate after cells
transplantation. Molecular Imaging approaches enabling noninvasive long-term monitoring …

Through preimplantation genetic diagnosis, genetic diseases can be detected during the
early stages of embryogenesis, but effective treatments for many of these disorders are …

Technologies designed to allow manipulation and modification of human embryonic stem
(hES) cells are numerous and vary in the complexity of their methods, efficiency, reliability …

Abstract Development of non-invasive and accurate methods to track cell fate after delivery
will greatly expedite transition of embryonic stem (ES) cell therapy to the clinic. In this …

In the past 2 years, new gene-targeting approaches using adeno-associated virus and
designer zinc-finger nucleases have been successfully applied to the production of …