Imaging the intratumoral distribution of an EGFR-targeting antibody in a tumor mouse model using high-resolution focusing pinhole SPECT
E Blezer, R Ramakers, J van den Brakel, J Oprins… - 2009 - Soc Nuclear Med
1566 Objectives Many tumor-targeting therapeutic human monoclonal antibodies (HMab)
are evaluated in preclinical animal research. However the in vivo visualization of the …
are evaluated in preclinical animal research. However the in vivo visualization of the …
Three-dimensional histologic validation of high-resolution SPECT of antibody distributions within xenografts
W Branderhorst, ELA Blezer, M Houtkamp… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Longitudinal imaging of intratumoral distributions of antibodies in vivo in mouse cancer
models is of great importance for developing cancer therapies. In this study, multipinhole …
models is of great importance for developing cancer therapies. In this study, multipinhole …
Development of ABT-806i, a Kit-formulated 111In-ABT-806 antibody directed to EGFR for tumor imaging
Y Zhang, T Cole, A Phillips, J Meulbroek, T Merdan… - 2013 - Soc Nuclear Med
396 Objectives ABT-806 is a humanized antibody targeting a unique epitope on EGFR only
available for binding when EGFR is overexpressed, activated, or when the EGFRvIII …
available for binding when EGFR is overexpressed, activated, or when the EGFRvIII …
Evaluation of a radiolabeled anti-EGFR antibody for a tumor imaging probe
BS Kim, EJ Kim, DB Choi, CH Yi, SJ Han, TH Choi - 2014 - Soc Nuclear Med
1061 Objectives Noninvasive imaging of the epidermal growth factor receptor (EGFR) in
tumors could be valuable to select patients for EGFR-targeted therapy. EG0118 is a new …
tumors could be valuable to select patients for EGFR-targeted therapy. EG0118 is a new …
SPECT Imaging with 99mTc-Labeled EGFR-Specific Nanobody for In Vivo Monitoring of EGFR Expression
L Huang, LOT Gainkam, V Caveliers… - Molecular imaging and …, 2008 - Springer
Purpose Overexpression of the epidermal growth factor receptor (EGFR) occurs with high
incidence in various carcinomas. The oncogenic expression of the receptor has been …
incidence in various carcinomas. The oncogenic expression of the receptor has been …
Molecular Imaging of EGFR-Expressing Tumors with Novel Targeted Protein Scaffold, anti-EGFR Repebody
500 Objectives Repebody is a binding scaffold based on variable lymphocyte receptors,
which are nonimmunoglobulin antibodies composed of leucine-rich repeat modules in …
which are nonimmunoglobulin antibodies composed of leucine-rich repeat modules in …
111In-cetuximab-F (ab') 2 SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts
LK van Dijk, BAW Hoeben, H Stegeman… - Radiotherapy and …, 2013 - Elsevier
Background and purpose Immunohistochemical epidermal growth factor receptor (EGFR)
expression does not correlate with treatment response in head and neck squamous cell …
expression does not correlate with treatment response in head and neck squamous cell …
A model system to explore the detection limits of antibody-based immuno-SPECT imaging of exclusively intranuclear epitopes
M Veal, G Dias, V Kersemans, D Sneddon… - Journal of Nuclear …, 2021 - Soc Nuclear Med
Imaging of intranuclear epitopes using antibodies tagged to cell-penetrating peptides has
great potential given its versatility, specificity, and sensitivity. However, this process is …
great potential given its versatility, specificity, and sensitivity. However, this process is …
Comparison of the biodistribution and tumor targeting of two 99mTc-labeled anti-EGFR nanobodies in mice, using pinhole SPECT/micro-CT
LOT Gainkam, L Huang, V Caveliers… - Journal of Nuclear …, 2008 - Soc Nuclear Med
Camelidae possess an unusual class of antibodies devoid of light chains. Nanobodies are
intact antigen-binding fragments that are stable, easily generated against different targets …
intact antigen-binding fragments that are stable, easily generated against different targets …
{sup 111} In-cetuximab-F (ab'){sub 2} SPECT imaging for quantification of accessible epidermal growth factor receptors (EGFR) in HNSCC xenografts
LK Dijk, BAW Hoeben, H Stegeman… - Radiotherapy and …, 2013 - osti.gov
Background and purpose: Immunohistochemical epidermal growth factor receptor (EGFR)
expression does not correlate with treatment response in head and neck squamous cell …
expression does not correlate with treatment response in head and neck squamous cell …