107 Objectives Alpha-1 noradrenergic receptors are thought to contribute to the
pathophysiology of anxiety symptoms in patients with post-traumatic stress disorder (PTSD) …

32 Objectives A PET ligand for the adrenergic α2 receptor (α2AR) would be of interest for
accelerating drug development aimed at this receptor. R129144 has high affinity and …

Increased central nervous system CNS alpha-1 noradrenergic receptor 1NAR responsivity
may be a vulnerability andor diagnostic biomarker for posttraumatic stress disorder PTSD …

Aberrations in the {alpha}{sub 2}-adrenergic receptor system have been implicated in a
number of disease states including hypertension, drug abuse, depression, and …

Reduced density of the α4β2 nicotinic acetylcholine receptor (α4β2-nAChR) in the cortex
and hippocampus of the human brain has been reported in aging and patients with …

In vitro studies showed that MK-912 ((2S, 12bS) 1', 3'-dimethylspiro (1, 3, 4, 5', 6, 6', 7, 12b-
octahydro-2H-benzo [b] furo [2, 3-a] quinolizine)-2, 4'-pyrimidin-2'-one) is a potent α2 …

In vitro studies showed that MK-912 ((2S, 12bS) 1', 3'-dimethylspiro (1, 3, 4, 5', 6, 6', 7, 12b-
octahydro-2H-benzo [b] furo [2, 3-a] quinolizine)-2, 4'-pyrimidin-2'-one) is a potent …

2860 Introduction: The a2C-adrenergic receptors (a2C-ARs) are presynaptic receptors that
inhibit neurotransmitter release from adrenergic brain terminals and are targets of interest for …

490 Objectives We have developed the agonist 18 F-nifene for PET imaging studies of
nicotinic α4β2 receptors in various CNS disorders. Upon successful completion of rodent …

1225 Objectives: β-Adrenergic receptors (βARs) have been evaluated with PET for both
heart and neurological imaging. Current methods to prepare [18 F]-labeled β-blockers …