Targeting angiogenesis for radioimmunotherapy with 177Lu

E Ehlerding, D Jiang, S Goel, R Hernandez, J Jeffery… - 2017 - Soc Nuclear Med
457 Objectives: Increased angiogenesis is a marker of aggressiveness in many cancers.
Targeted radionuclide therapy of these cancers with angiogenesis-targeting agents may …

Targeting angiogenesis for radioimmunotherapy with a 177Lu-labeled antibody

EB Ehlerding, S Lacognata, D Jiang… - European journal of …, 2018 - Springer
Purpose Increased angiogenesis is a marker of aggressiveness in many cancers. Targeted
radionuclide therapy of these cancers with angiogenesis-targeting agents may curtail this …

Radiolabeling of monoclonal anti-CD105 with 177Lu for potential use in radioimmunotherapy

SY Lee, YD Hong, PM Felipe, MS Pyun… - Applied Radiation and …, 2009 - Elsevier
In this study, we carried out a radioimmunoconjugation using 177Lu with anti-CD105
(endoglin) monoclonal antibody for an angiogenesis targeting. CD105 has been shown to …

[PDF][PDF] Radiolabeling of Monoclonal Anti-CD105 with 177 Lu for Tumor Diagnosis and Therapy via Angiogenesis Targeting

L So-Young, PM Felipe, YD Hong, SJ Choi - kns.org
Currently, great interest is focused on angiogenesis and on its potential clinical implications
in cancer. An intriguing approach relies on the selective targeting of the surface molecules …

86/90Y-based theranostics of breast cancer in a preclinical model

E Ehlerding, C Ferreira, E Aluicio-Sarduy, D Jiang… - 2018 - Soc Nuclear Med
539 Objectives: Angiogenesis is one of the hallmarks of cancer, enabling increased tumor
growth and metastasis. Therefore, imaging of angiogenesis may enable sensitive detection …

Radiolabeling of Monoclonal Anti-CD105 with {sup 177} Lu for Tumor Diagnosis and Therapy via Angiogenesis Targeting

SY Lee, PM Felipe, YD Hong, SJ Choi - 2008 - osti.gov
Currently, great interest is focused on angiogenesis and on its potential clinical implications
in cancer. An intriguing approach relies on the selective targeting of the surface molecules …

In vivo near-infrared fluorescence imaging of CD105 expression

Y Yang, H Hong, Y Zhang, B Leigh, W Cai - 2011 - Soc Nuclear Med
232 Objectives Angiogenesis is an indispensable process during tumor development.
Microvessel density (MVD) assessment based on CD105 staining is an independent …

PET of CD105 expression with a 61/64Cu-labeled Fab antibody fragment

Y Zhang, H Hong, H Orbay, T Barnhart, C Theuer… - 2013 - Soc Nuclear Med
395 Objectives To generate and characterize the Fab fragment of TRC105, a monoclonal
antibody that binds with high affinity to human and murine CD105 (ie endoglin), and …

Dual-modality PET and optical imaging of CD105 expression in breast cancer

Y Zhang, H Hong, Y Yang, J Engle, C Theuer… - 2012 - Soc Nuclear Med
70 Objectives Overexpression of CD105 (ie endoglin) correlates with poor prognosis in> 10
solid tumor types. Tumor microvessel density assessed by CD105 staining is the current …

Syndecan-1 (CD138) antigen targeting using a I-131-labeled anti-CD138 antibody in human breast cancer xenografted nude mice

C Rousseau, F Kraeber-Bodere, K Bernardeau… - 2007 - Soc Nuclear Med
1490 Objectives: High syndecan-1 (CD 138) expression proved to be a new independent
prognostic marker for breast carcinoma and was related to an aggressive phenotype and …