Patients with secondary progressive multiple sclerosis (SPMS) are lacking efficient
medication to slow down the progression of their disease. PET imaging holds promise as a …

Conventional MR imaging (MRI) techniques form the cornerstone of multiple sclerosis (MS)
diagnostics and clinical follow-up today. MRI is sensitive in demonstrating focal inflammatory …

Purpose Expression of the translocator protein (TSPO) is upregulated in activated
macrophages/microglia and is considered to be a marker of neuroinflammation. We …

Background PET ligands targeting the translocator protein (TSPO) represent promising tools
to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and …

Background The activation of microglia, in general, and the upregulation of the translocator
protein (18 kDa)(TSPO) system, in particular, are key features of neuroinflammation, of …

The objective of this study was to assess microglial activation in lesions and in normal-
appearing white matter (NAWM) of multiple sclerosis (MS) patients using PET. Methods …

Glial activation in the setting of central nervous system inflammation is a key feature of the
multiple sclerosis (MS) pathology. Monitoring glial activation in subjects with MS, therefore …

PET radioligand binding to the 18-kD translocator protein (TSPO) in the brains of patients
with multiple sclerosis (MS) primarily reflects activated microglia and macrophages. We …

Understanding the mechanisms underlying progression in multiple sclerosis (MS) is one of
the key elements contributing to the identification of appropriate therapeutic targets for this …

Background Over the past decades, positron emission tomography (PET) imaging has
become an increasingly useful research modality in the field of multiple sclerosis (MS) …