These studies highlight several factors that affect monoclonal antibody (Mab) localization to
a tumor in the brain, including tumor permeability, nonspecific and specific binding, plasma …

The pharmacokinetics and regional tissue distribution of two IgG2b immunoglobulins were
studied in athymic mice with D54MG human glioma xenografts. Monoclonal antibody (Mab) …

OBJECTIVE: The SGN-15 monoclonal antibody-doxorubicin immunoconjugate is toxic to
Lewis Y antigen-expressing cells and is effective against intracerebral tumors in nude rats …

Abstract Iodinated monoclonal antibodies (IgG 96.5 and two monomeric Fab fragments 96.5
and 48.7) to melanoma-associated antigens were administered after osmotic blood-brain …

Multiple fusions following immunization of athymic mice with the extensively characterized
human glioma cell line D-54 MG resulted in the selection of several antibodies (Mabs) highly …

The murine antiglioma monoclonal antibody 81C6 has been shown to specifically localize in
U-251 MG and D-54 MG human glioma subcutaneous and intracranial athymic mouse …

Delivery of monoclonal antibodies (Mab) to brain tumors is restricted by the blood: brain
barrier. To circumvent this problem, we studied direct stereotactic injection of the Mab into …

Monoclonal antibody UJ13A, radiolabelled with 131 I, was intravenously administered to
patients with primary brain tumours. The antigen recognised by UJ13A is present on most …

Purpose: The objective of this study was to evaluate the efficacy of sequencing radiation
therapy (RT) and antibody targeted chemotherapy (BR96-DOX) in nude rats bearing human …

We evaluated the delivery of melanoma-specific radiolabeled monoclonal antibody (MAb)
Fab fragments in a pilot study of three patients with melanoma metastatic to the central …