Evaluation of a mitochondrial voltage sensor,(18F-fluoropentyl) triphenylphosphonium cation, in a rat myocardial infarction model
DY Kim, HS Kim, UN Le, SN Jiang, HJ Kim… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Radiolabeled lipophilic cationic compounds, such as 18F-labeled phosphonium salt,
accumulate in the mitochondria through a negative inner transmembrane potential. The …
accumulate in the mitochondria through a negative inner transmembrane potential. The …
[PDF][PDF] Synthesis of (4-Fluorophenyl)triphenylphosphonium as a Mitochondrial Voltage Sensor for PET
DY Kim, KH Yu, HS Bom, JJ Min - Nuclear Medicine and Molecular …, 2007 - koreascience.kr
Purpose: Lipophilic cations including tetraphenylphosphonium (TPP) salts penetrate the
hydrophobic barriers of the plasma and mitochondrial membranes, resulting in accumulation …
hydrophobic barriers of the plasma and mitochondrial membranes, resulting in accumulation …
Evaluation of (4-[18F]Fluorophenyl)triphenylphosphonium Ion. A Potential Myocardial Blood Flow Agent for PET
TM Shoup, DR Elmaleh, AL Brownell, A Zhu… - Molecular Imaging and …, 2011 - Springer
Purpose The lipophilic cationic compound,(4-[18 F] fluorophenyl) triphenylphosphonium ion
(18 F-FTPP) was synthesized and evaluated as a potential positron emission tomography …
(18 F-FTPP) was synthesized and evaluated as a potential positron emission tomography …
Radiolabeled phosphonium salts as mitochondrial voltage sensors for positron emission tomography myocardial imaging agents
DY Kim, JJ Min - Nuclear medicine and molecular imaging, 2016 - Springer
Despite substantial advances in the diagnosis of cardiovascular disease, 18 F-labeled
positron emission tomography (PET) radiopharmaceuticals remain necessary to diagnose …
positron emission tomography (PET) radiopharmaceuticals remain necessary to diagnose …
4-[18F]-Tetraphenylphosphonium as a PET Tracer for Myocardial Mitochondrial Membrane Potential
GS Gurm, SB Danik, TM Shoup, S Weise… - JACC: Cardiovascular …, 2012 - jacc.org
Objectives: This study tested the hypothesis that 4-[18F] fluorophenyltriphenylphosphonium
(18F-TPP) is useful for in vivo positron emission tomography (PET) measurement of …
(18F-TPP) is useful for in vivo positron emission tomography (PET) measurement of …
Highly efficient one-pot labeling of new phosphonium cations with fluorine-18 as potential PET agents for myocardial perfusion imaging
Z Zhao, Q Yu, T Mou, C Liu, W Yang… - Molecular …, 2014 - ACS Publications
Lipophilic cations such as phosphonium salts can accumulate in mitochondria of heart in
response to the negative inner-transmembrane potentials. Two phosphonium salts [18F] …
response to the negative inner-transmembrane potentials. Two phosphonium salts [18F] …
Synthesis of [18F]-labeled (2-(2-fluoroethoxy) ethyl) tris (4-methoxyphenyl) phosphonium cation as a potential agent for positron emission tomography myocardial …
DY Kim, HJ Kim, KH Yu, JJ Min - Nuclear medicine and biology, 2012 - Elsevier
INTRODUCTION: Established radiotracers for positron emission tomography (PET)
myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit …
myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit …
Synthesis of [18F]-labeled (2-(2-fluoroethoxy) ethyl) triphenylphosphonium cation as a potential agent for myocardial imaging using positron emission tomography
DY Kim, HJ Kim, KH Yu, JJ Min - Bioorganic & medicinal chemistry letters, 2012 - Elsevier
[18F]-labeled molecular probe for the detection of myocardial perfusion deficit is driving
particular interest due to its high clinical applicability. Thus, we synthesized (2-(2-[18F] …
particular interest due to its high clinical applicability. Thus, we synthesized (2-(2-[18F] …
Synthesis of [18F]-Labeled (6-Fluorohexyl)triphenylphosphonium Cation as a Potential Agent for Myocardial Imaging using Positron Emission Tomography
DY Kim, HJ Kim, KH Yu, JJ Min - Bioconjugate chemistry, 2012 - ACS Publications
Lipophilic cations such as phosphonium salts penetrate the hydrophobic barriers of the
plasma and mitochondrial membranes and accumulate in mitochondria in response to the …
plasma and mitochondrial membranes and accumulate in mitochondria in response to the …
Characterization of uptake of the new PET imaging compound 18F-fluorobenzyl triphenyl phosphonium in dog myocardium
18F-Labeled p-fluorobenzyl triphenyl phosphonium cation (18F-FBnTP) is a member of a
new class of positron-emitting lipophilic cations that may act as myocardial perfusion PET …
new class of positron-emitting lipophilic cations that may act as myocardial perfusion PET …