Objectives The objective is to use longitudinal quantitative FDG and amyloid PET
measurements to map genetic risk factors for Alzheimer's disease based on WGS data. 75 …

Background Alzheimer's disease (AD) is a complex disease in which the quest for causative
genes has been challenging. In this search, genome-wide studies (GWAS) have been a …

1060 Objectives: Alzheimer's disease (AD) is characterized by the aggregation of two types
of pathological proteins, tau and amyloid-β. Our objective here is to evaluate whether and to …

583 Objectives: The semi-automated Biomarker Localization, Analysis, Visualization,
Extraction, and Registration (BLAzER) workflow allows for rapid evaluation of MRI and …

Background The pathology of AD begins to accumulate years before the development of
clinical disease. Radiolabeled ligands that bind to such pathology allow us to visualize …

1569 Objectives To evaluate the diagnostic potential of glucose metabolism, amyloid
deposition measured by PET and CSF biomarkers in monitoring the progression from mild …

The precise role of environment-gene interactions (epigenetics) in the development and
progression of Alzheimer's disease (AD) is unclear. This review focuses on the premise that …

930 Objectives: Supported by compelling genetic data associated with the rare early onset
familial Alzheimer's disease (FAD), the Aβcentric theory states that Aβ is involved in the …

193 Objectives Deposition of β-amyloid (Aβ) plays a major role in the pathophysiology of
Alzheimer's disease (AD) and is sensitively detectable by recently developed PET-tracers …

512 Objectives This study is to investigate topographical analysis of peak location of cortical
laminar deposition of amyloid tracer uptake within gray matter and its potential diagnostic …