Safety analysis of 10 clinical trials and for 13 years after first approval of ioflupane 123I injection (DaTscan)

DG Grosset, K Tatsch, WH Oertel… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Ioflupane is an analog of cocaine that binds reversibly with high affinity to the dopamine
transporter (DaT) protein, a marker for presynaptic terminals in dopaminergic nigrostriatal …

SNM practice guideline for dopamine transporter imaging with 123I-ioflupane SPECT 1.0

DSW Djang, MJR Janssen, N Bohnen… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Nv-fluoropropyl-2b-carbomethoxy-3b-(4-123I-iodophenyl) nortropane (123I-ioflupane) is a
molecular imaging agent used to demonstrate the location and concentration of dopamine …

A new era of clinical dopamine transporter imaging using 123I-FP-CIT

E Park - Journal of nuclear medicine technology, 2012 - Soc Nuclear Med
123I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane (123I-FP-
CIT) was approved for clinical use in 2011 by the Food and Drug Administration. 123I-FP …

Perspective on how the FDA should review diagnostic radiopharmaceuticals

SW Schwarz, B Clarke - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
This article provides readers with some background on concerns raised by Dr. Marcus about
the evaluation of radiopharmaceuticals in this issue of The Journal of Nuclear Medicine (1) …

Iodine-123 labelledN-(2-fluoroethyl)-2β-carbomethoxy-3β-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain

JT Kuikka, K Åkerman, KA Bergström, J Karhu… - European journal of …, 1995 - Springer
There are several cocaine analogs which have potential for imaging the dopamine
transporters (DAT). Earlier studies have shown that iodine-123 labelled 2β-carbomethoxy …

Whole-body distribution and radiation dosimetry of the dopamine transporter radioligand [11C] PE2I in healthy volunteers

MJ Ribeiro, M Ricard, MA Lièvre, S Bourgeois… - Nuclear medicine and …, 2007 - Elsevier
INTRODUCTION: This study reports on the biodistribution and radiation dosimetry of a
cocaine analog, the (E)-N-(3-iodoprop-2-enyl)-2β-carbomethoxy-3β-(4′-tolyl) nortropane …

Clinical testing of an optimized software solution for an automated, observer-independent evaluation of dopamine transporter SPECT studies

W Koch, PE Radau, C Hamann… - Journal of Nuclear …, 2005 - Soc Nuclear Med
A lack of standardized evaluation procedures for dopamine transporter (DAT) SPECT
investigations impairs both intra-and interindividual comparisons as well as multicenter trials …

Acute administration of haloperidol does not influence 123I-FP-CIT binding to the dopamine transporter

J Booij, G van Loon, K de Bruin… - Journal of Nuclear …, 2014 - Soc Nuclear Med
A recent 123I-FP-CIT (123-IN-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)
nortropane) SPECT study on rats suggested that a single 1 mg/kg dose of the antipsychotic …

[HTML][HTML] A systematic review of the potential effects of medications and drugs of abuse on dopamine transporter imaging using [123I]I-FP-CIT SPECT in routine …

Y Chahid, ZH Sheikh, M Mitropoulos, J Booij - European journal of nuclear …, 2023 - Springer
Purpose In routine practice, dopamine transporter (DAT) imaging is frequently used as a
diagnostic tool to support the diagnosis of Parkinson's disease or dementia with Lewy …

Comparison of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of …

JT Kuikka, KA Bergström, A Ahonen, J Hiltunen… - European journal of …, 1995 - Springer
Several cocaine congeners are of potential for imaging the dopamine transporter (DAT).
Previous studies have shown that iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl) …