Quantitative preclinical imaging of TSPO expression in glioma using N, N-diethyl-2-(2-(4-(2-18F-fluoroethoxy) phenyl)-5, 7-dimethylpyrazolo [1, 5-a] pyrimidin-3-yl) …
There is a critical need to develop and rigorously validate molecular imaging biomarkers to
aid diagnosis and characterization of primary brain tumors. Elevated expression of …
aid diagnosis and characterization of primary brain tumors. Elevated expression of …
Preclinical Imaging Evaluation of Novel TSPO-PET Ligand 2-(5,7-Diethyl-2-(4-(2-[18F]fluoroethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide ([18 …
Purpose Translocator protein (TSPO) concentrations are elevated in glioma, suggesting a
role for TSPO positron emission tomography (PET) imaging in this setting. In preclinical PET …
role for TSPO positron emission tomography (PET) imaging in this setting. In preclinical PET …
Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2, 5-dimethoxybenzyl)-2-phenoxyaniline
Translocator protein (TSPO), also referred to as peripheral benzodiazepine receptor (PBR),
is a crucial 18-kDa outer mitochondrial membrane protein involved in numerous cellular …
is a crucial 18-kDa outer mitochondrial membrane protein involved in numerous cellular …
[HTML][HTML] TSPO expression in brain tumours: is TSPO a target for brain tumour imaging?
Positron emission tomography (PET) alone or in combination with MRI is increasingly
assuming a central role in the development of diagnostic and therapeutic strategies for brain …
assuming a central role in the development of diagnostic and therapeutic strategies for brain …
[HTML][HTML] The translocator protein ligand [18F]DPA-714 images glioma and activated microglia in vivo
A Winkeler, R Boisgard, AR Awde, A Dubois… - European journal of …, 2012 - Springer
Purpose In recent years there has been an increase in the development of radioligands
targeting the 18-kDa translocator protein (TSPO). TSPO expression is well documented in …
targeting the 18-kDa translocator protein (TSPO). TSPO expression is well documented in …
[HTML][HTML] Longitudinal [18F]GE-180 PET Imaging Facilitates In Vivo Monitoring of TSPO Expression in the GL261 Glioblastoma Mouse Model
A Holzgreve, D Pötter, M Brendel, M Orth, L Weidner… - Biomedicines, 2022 - mdpi.com
The 18 kDa translocator protein (TSPO) is increasingly recognized as an interesting target
for the imaging of glioblastoma (GBM). Here, we investigated TSPO PET imaging and …
for the imaging of glioblastoma (GBM). Here, we investigated TSPO PET imaging and …
[HTML][HTML] Preclinical TSPO ligand PET to visualize human glioma xenotransplants: a preliminary study
JR Buck, ET McKinley, A Fu, TW Abel, RC Thompson… - PloS one, 2015 - journals.plos.org
Current positron emission tomography (PET) imaging biomarkers for detection of infiltrating
gliomas are limited. Translocator protein (TSPO) is a novel and promising biomarker for …
gliomas are limited. Translocator protein (TSPO) is a novel and promising biomarker for …
Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans
Translocator protein (TSPO) is upregulated in activated microglia and thus can serve as a
marker of neuroinflammation. Recently, a novel radioligand, 11C-N, N-diethyl-2-[2-(4 …
marker of neuroinflammation. Recently, a novel radioligand, 11C-N, N-diethyl-2-[2-(4 …
[HTML][HTML] Evaluation of PET Imaging Performance of the TSPO Radioligand [18F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation
J Zheng, A Winkeler, MA Peyronneau, F Dollé… - Molecular imaging and …, 2016 - Springer
Purpose Many radioligands have been explored for imaging the 18-kDa translocator protein
(TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we …
(TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we …
Positron-Emission Tomography Imaging of the TSPO with [18F]FEPPA in a Preclinical Breast Cancer Model
N Vasdev, DE Green, DC Vines, K McLarty… - Cancer Biotherapy …, 2013 - liebertpub.com
The present study aims to image the 18-kDa translocator protein (TSPO; formerly known as
the peripheral benzodiazepine receptor) in a preclinical human breast cancer (BC) …
the peripheral benzodiazepine receptor) in a preclinical human breast cancer (BC) …