1695 Objectives: The role of chemokine receptor 2 (CCR2) has been elucidated in the
development of idiopathic pulmonary fibrosis (IPF). This inflammatory disease, with limited …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease
without effective molecular markers of disease activity or treatment responses. Monocyte …

Rationale. Pulmonary fibrosis is thought to be the result of a poorly understood injury and
dysregulated repair response leading to diverse interstitial lung diseases that are both …

Lung CCR2+(Chemokine receptor 2) inflammatory monocytes are elevated in the lungs of
patients with pulmonary fibrosis and in preclinical models of lung fibrosis. Genetic depletion …

483 Objectives Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by
progressive respiratory failure, and limited therapeutic options. The chemokine receptor …

Purpose To characterize a chemokine receptor type 2 (CCR2)–binding peptide adapted for
use as a positron emission tomography (PET) radiotracer for noninvasive detection of lung …

Rationale: Progressive fibrotic lung disease is characterized by a population of profibrotic
interstitial macrophages derived from CCR2+ monocytes that egress from bone marrow to …

Interstitial lung diseases (ILDs) are a heterogeneous group of parenchymal pulmonary
disorders. Their hallmark is pulmonary infiltration by immune-competent cells followed by …

There is a large unmet need for a simple, accurate, noninvasive, quantitative, and high-
resolution imaging modality to detect lung fibrosis at early stage and to monitor disease …

Interstitial lung diseases (ILDs) are a heterogeneous group of parenchymal pulmonary
disorders. Their hallmark is pulmonary infiltration by immune-competent cells followed by …