PSMA-targeted radionuclide therapy and salivary gland toxicity: why does it matter?

D Taïeb, JM Foletti, M Bardiès, P Rocchi… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The promise of prostate-specific membrane antigen (PSMA)–targeted radionuclide therapy
is being demonstrated by a growing number of reports detailing institutional experience with …

[HTML][HTML] The salivary glands as a dose limiting organ of PSMA-targeted radionuclide therapy: a review of the lessons learnt so far

N Heynickx, K Herrmann, K Vermeulen… - Nuclear medicine and …, 2021 - Elsevier
At present, prostate cancer remains the second most occurring cancer in men, in Europe.
Treatment efficacy for therapy of advanced metastatic disease, and metastatic castration …

Salivary gland toxicity of PSMA radioligand therapy: relevance and preventive strategies

T Langbein, G Chaussé, RP Baum - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
Since the first clinical use of 131I-labeled prostate-specific membrane antigen (PSMA)(1),
xerostomia has been identified as a relevant side effect of PSMA radioligand therapies …

Why targeting PSMA is a game changer in the management of prostate cancer

NM Donin, RE Reiter - Journal of Nuclear Medicine, 2018 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein that is highly
expressed on prostate adenocarcinomas, exhibits only limited expression in benign and …

[HTML][HTML] Salivary Gland Toxicity of PSMA-Targeted Radioligand Therapy with 177Lu-PSMA and Combined 225Ac- and 177Lu-Labeled PSMA Ligands (TANDEM …

T Langbein, HR Kulkarni, C Schuchardt, D Mueller… - Diagnostics, 2022 - mdpi.com
Purpose: PSMA-targeted radioligand therapy (PRLT) is a promising treatment option for
patients with metastatic castration-resistant prostate cancer (mCRPC). However, a high …

[HTML][HTML] PSMA theranostics: science and practice

K Mokoala, I Lawal, T Lengana, M Kgatle, FL Giesel… - Cancers, 2021 - mdpi.com
Simple Summary A significant number of prostate cancer patients will progress to metastatic
castrate resistant prostate cancer despite optimal therapies. There is a growing need for …

[HTML][HTML] Assessment of salivary gland function after 177Lu-PSMA radioligand therapy: Current concepts in imaging and management

S Mahajan, RK Grewal, KP Friedman, H Schöder… - Translational …, 2022 - Elsevier
Prostate specific membrane antigen (PSMA) is a transmembrane protein that is highly
expressed on prostate epithelial cells and is strongly upregulated in prostate cancer …

[HTML][HTML] The future of PSMA-targeted radionuclide therapy: an overview of recent preclinical research

EAM Ruigrok, WM van Weerden, J Nonnekens… - Pharmaceutics, 2019 - mdpi.com
Prostate specific membrane antigen (PSMA) has become a major focus point in the research
and development of prostate cancer (PCa) imaging and therapeutic strategies using …

[HTML][HTML] PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports

MJM Uijen, YHW Derks, RIJ Merkx… - European journal of …, 2021 - Springer
In the past decade, a growing body of literature has reported promising results for prostate-
specific membrane antigen (PSMA)-targeted radionuclide imaging and therapy in prostate …

Radionuclide therapy in prostate cancer: from standalone to combination PSMA theranostics

S Sandhu, C Guo, MS Hofman - Journal of Nuclear Medicine, 2021 - Soc Nuclear Med
Despite significant advances in therapeutic developments for prostate cancer over the last 2
decades, metastatic prostate cancer remains a lethal disease. Prostate-specific membrane …