The norepinephrine analog 11C-meta-hydroxyephedrine (HED) is used with PET to map the
regional distribution of cardiac sympathetic neurons. HED is rapidly transported into …

11C-meta-Hydroxyephedrine (HED) is used in cardiac PET as an index of norepinephrine
(NE) reuptake transporter (NET) density and synaptic NE levels. Whereas cardiac uptake is …

INTRODUCTION: The norepinephrine analogue 11C-meta-hydroxyephedrine (HED) has
been used to interrogate sympathetic neuronal reuptake in cardiovascular disease …

The purpose of this study was to validate an axially distributed blood-tissue exchange model
for the quantitation of cardiac presynaptic sympathetic nervous system function that could be …

Depart@ nent ofInterna1Medichze@ Divirion ofNuclear Medicine, University ofMichwan
Medical Center, Ann Arbor, Michigan cholarnine levels or sympathetic nervous tone …

Dysfunction of the sympathetic nervous system underlies many cardiac diseases and can be
assessed by molecular imaging using PET in humans. Small-animal PET should enable …

We aimed to explore the impact of ageing on 11C-hydroxyephedrine (11C-HED) uptake in
the healthy rat heart in a longitudinal setting. To investigate a potential cold mass effect, the …

Abstract Purpose 11 C-Hydroxyephedrine (HED) and radioiodinated
metaiodobenzylguanidine (123 I/131 I-MIBG) are catecholamine analogue tracers for …

Most cardiac sympathetic nerve radiotracers are substrates of the norepinephrine
transporter (NET). Existing tracers such as 123I-metaiodobenzylguanidine (123I-MIBG) and …

18F-N-[3-bromo-4-(3-fluoro-propoxy)-benzyl]-guanidine (18F-LMI1195) is a new PET tracer
designed for noninvasive assessment of sympathetic innervation of the heart. The 18F label …