[PDF][PDF] Pretargeted immunoscintigraphy: effect of hapten valency on murine tumor uptake
DA Goodwin, CF Meares, M McTigue… - Journal of Nuclear …, 1992 - Soc Nuclear Med
(S)-lp-aminobenzyl-EDTA, prepared as described earlier (9, 11), was added to 18 ml of H20,
the pH adjusted to 7.4 using 3 M NaOH and then 489 zlof neat diisopropylethylamine added …
the pH adjusted to 7.4 using 3 M NaOH and then 489 zlof neat diisopropylethylamine added …
[PDF][PDF] Radioimmunolocalization of metastatic breast carcinoma using indium-111-methyl benzyl DTPA BrE-3 monoclonal antibody: phase I study
EL Kramer, SJ DeNardo, L Liebes… - Journal of Nuclear …, 1993 - Soc Nuclear Med
Imaging Quantitative planar imagingwas performed to determine phar macokinetics and
tumor localization (19, 20). All images were ob tamed using a large field of view gamma …
tumor localization (19, 20). All images were ob tamed using a large field of view gamma …
[PDF][PDF] Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens
DA Goodwin, CF Meares, MJ McCall… - Journal of nuclear …, 1988 - Soc Nuclear Med
A method of tumor imaging utilizingthe nonspecific accumulation of antibody through leaky
capillaries is described, in which the antibody and the radiolabel are administered …
capillaries is described, in which the antibody and the radiolabel are administered …
Tumor pretargeting in mice using 99mTc-labeled morpholino, a DNA analog
G Liu, K Mang'era, N Liu, S Gupta… - Journal of Nuclear …, 2002 - Soc Nuclear Med
Over the past several years, investigators in this laboratory and elsewhere have been
studying tumor localization by pretargeting with streptavidin and biotin or with avidin and …
studying tumor localization by pretargeting with streptavidin and biotin or with avidin and …
Iodine-131 and indium-111 labelled avidin and streptavidin for pre-targetted immunoscintigraphy with biotinylated anti-tumour monoclonal antibody
MV Pimm, HF Fells, AC Perkins, RW Baldwin - 1988 - journals.lww.com
Studies have been carried out in mice to examine by gamma camera imaging and
dissection analysis the biodistribution of 131 I-and 111 In-labelled avidin and streptavidin …
dissection analysis the biodistribution of 131 I-and 111 In-labelled avidin and streptavidin …
[PDF][PDF] Effect of DTPA conjugation on the antigen binding activity and biodistribution of monoclonal antibodies against α-fetoprotein
H Sakahara, K Endo, T Nakashima… - Journal of nuclear …, 1985 - Soc Nuclear Med
Indium-111-(111ln) labeledmonoclonalantibodies (Ab) preparedwitha bifunctional
chelatingagent, diethylenefriaminepentaaceticacid (OWA), have been usedfor the …
chelatingagent, diethylenefriaminepentaaceticacid (OWA), have been usedfor the …
Positively charged templates for labeling internalizing antibodies: comparison of N-succinimidyl 5-iodo-3-pyridinecarboxylate and the D-amino acid peptide KRYRR
CF Foulon, PC Welsh, DD Bigner… - Nuclear medicine and …, 2001 - Elsevier
Receptor-mediated internalization of monoclonal antibodies (mAbs), such as those specific
for the epidermal growth factor receptor variant III (EGFRvIII), can lead to rapid loss of …
for the epidermal growth factor receptor variant III (EGFRvIII), can lead to rapid loss of …
Streptavidin in Antibody Pretargeting. 5. Chemical Modification of Recombinant Streptavidin for Labeling with the α-Particle-Emitting Radionuclides 213Bi and 211At
DS Wilbur, DK Hamlin, MK Chyan… - Bioconjugate …, 2008 - ACS Publications
We are investigating the use of recombinant streptavidin (rSAv) as a carrier molecule for the
short-lived α-particle-emitting radionuclides 213Bi (t 1/2= 45.6 min) and 211At (t 1/2= 7.21 h) …
short-lived α-particle-emitting radionuclides 213Bi (t 1/2= 45.6 min) and 211At (t 1/2= 7.21 h) …
Pretargeting: general principles; October 10–12, 1996
DA Goodwin, CF Meares - … International Journal of the …, 1997 - Wiley Online Library
BACKGROUND Human imaging studies show that maximum human tumor concentrations
of monoclonal antibody (MoAb) are achieved in 1 day, but several days are required for …
of monoclonal antibody (MoAb) are achieved in 1 day, but several days are required for …
Immuno-PET for tumor targeting
FT Lee, AM Scott - Journal of Nuclear Medicine, 2003 - Soc Nuclear Med
Monoclonal antibodies are approved for use as diagnostics and therapeutics in a broad
range of medical indications including transplantation, cardiology, inflammatory diseases …
range of medical indications including transplantation, cardiology, inflammatory diseases …