Improved synthesis and purification of C-11 PBR-28

D Yokell, N Nguyen, S Gallo, T L'Heureux, P Rice… - 2016 - Soc Nuclear Med
2720a Objectives C-11 PBR-28 has been reported in the literature to be difficult to be
purified and formulated into a readily injectable formulation for human use. Previous reports …

Improvement of C-11 radiopharmaceutical production using only ethanol as the organic solvent

X Shao, P Schnau, P Scott - 2012 - Soc Nuclear Med
1740 Objectives To simplify residual solvent analysis and speed up [11C] production, we
demonstrate the fully automated loop syntheses of 11C-Raclopride, 11C-DASB, and 11C …

Facile [11C]PIB Synthesis Using an On-cartridge Methylation and Purification Showed Higher Specific Activity than Conventional Method Using Loop and High …

YS Lee, YH Cho, HJ Lee, YS Lee… - The Korean Journal of …, 2018 - koreascience.kr
Abstract $[^{11} C] PIB $ synthesis has been performed by a loop-methylation and HPLC
purification in our lab. However, this method is time-consuming and requires complicated …

Effective synthesis of Pittsburg Compound B (11C-PIB) for clinical application by on-column 11C-methylation

A Yamada, S Baba, T Isoda, Y Maruoka, Y Kitamura… - 2015 - Soc Nuclear Med
1004 Objectives The Pittsburg Compound B (11 C-PIB) is a radiotracer for imaging amyloid
plaques in Alzheimer's disease by PET. The aim of this study was to develop an efficient fully …

Exploration of Two Loop Loading Methods in the Synthesis of C-11 PIB: The" Al-luer-ing" Details

L Floryance, G Stratton, D Dick - 2018 - Soc Nuclear Med
1077 Objectives: The objective of the study was to investigate two different methods of
loading the HPLC loop in production of 11 C-PIB (11 C Pittsburgh Compound B) with an eye …

Development of a fully automated method for radiosynthesis of fluorine-18 labeled CD8 PCC radiotracers

A Rosenberg, A Jackson, YY Cheung, F Liu, DC Parr… - 2021 - Soc Nuclear Med
1201 Objectives: The rise of cancer immunotherapies has resulted in an increased
emphasis on tumor immunology. There are a number of approved antibody-based immune …

Development and optimization of a novel automated loop method for production of11C-PK11195

A Ghosh, K Woolum, M Knopp, K Kumar - 2018 - Soc Nuclear Med
1054 Objectives: The objective of the present study was to develop and optimize a novel
automated loop method for production of 11 C-PK11195. Methods. In the automated …

High yield and semi-automated synthesis procedure of (R)-[11C] PK11195

P Chakraborty, D Maiti, T Mangner, D Chugani… - 2006 - Soc Nuclear Med
1900 Objectives: There has been a great deal of interest recently in applying (R)-[11 C]
PK11195 PET for neuropathologies involving neuroinflammation and activated microglia. In …

以 Eckert-Ziegler 模組系統自動合成 [C-11] PiB 程序之最佳化

CW Chang, CT Hung, WJ Yang, SP Chen… - 核子醫學暨分子影像 …, 2023 - airitilibrary.com
Background:[C-11] Pittsburgh Compound-B (PiB) is now almost routinely used to perform
clinical studies for patients in the neurological department at Taipei Veterans General …

Automated synthesis and biodistribution of {sup 11} C-PK11195

W Mingfang, T Ganghua, L Baoyuan… - Chinese Journal of …, 2008 - osti.gov
Objective: The aims of this study was to synthesize 1-(2-chlorophenyl)-N-[{sup 11} C] methyl-
N-(1-methylpropyl)-3-isoquinoline carboxamide ({sup 11} C-PK11195) on the commercial …