High levels of glucagon-like peptide-1 (GLP-1) receptor expression in human insulinomas
and gastrinomas provide an attractive target for imaging, therapy, and intraoperative tumor …

Purpose: Although metabolic changes make diagnosis of insulinoma relatively easy,
surgical removal is hampered by difficulties in locating it, and there is no efficient treatment …

Strong overexpression of glucagonlike peptide-1 (GLP-1) receptors in human insulinoma
provides an attractive target for imaging. The first clinical trials demonstrated that GLP-1 …

Internalizing agonists are usually selected for peptide receptor targeting. There is increasing
evidence that non‐internalizing receptor antagonists can be used for this purpose. We …

Purpose Glucagon-like peptide type 1 (GLP-1) is an incretin peptide that augments glucose-
stimulated insulin release following oral consumption of nutrients. Its message is transmitted …

Purpose Insulinomas are neuroendocrine tumours derived from pancreatic β-cells. The
glucagon-like peptide 1 receptor (GLP-1R) is expressed with a high incidence (> 90%) and …

Introduction: The GLP-1 receptor plays an important role in glucose homeostasis and thus is
a very important target for diabetes therapy. The receptor is also overexpressed in …

EXPERIMENTAL OBJECTIVES: In vivo imaging of GLP-1 receptor-positive tissues may
allow examination of physiologic and pathophysiologic processes. Based on the GLP-1 …

The glucagonlike peptide 1 receptor (GLP-1R) is mainly expressed on β-cells in the islets of
Langerhans and is therefore an attractive target for imaging of the β-cell mass. In the present …

As highly expressed in insulinomas, the glucagon-like peptide-1 receptor (GLP-1R) is
believed to be an attractive target for diagnosis, localization, and treatment with radiolabeled …