Initial Clinical Evaluation of [18F] DASA-23, a PET Imaging Tracer for Evaluation of Aberrantly Expressed Pyruvate Kinase M2 in Glioblastoma

C Beinat, C Patel, T Haywood, L Naya, J Castillo… - 2021 - Soc Nuclear Med
99 Introduction: Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key
process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) …
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[HTML] nih.gov

A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma

C Beinat, CB Patel, T Haywood, S Murty, L Naya… - Clinical Cancer …, 2021 - AACR
Abstract Purpose: Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, a key
process of cancer metabolism. PKM2 is preferentially expressed by glioblastoma (GBM) …
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Evaluation of [18F] DASA-23 for non-invasive measurement of aberrantly expressed pyruvate kinase M2 in glioblastoma: Preclinical and first in human studies

C Beinat, C Patel, T Haywood, S Murty, I Alam, Y Xie… - 2019 - Soc Nuclear Med
52 Objectives: We set out to develop 1-((2-fluoro-6-(fluoro-[18F]) phenyl) sulfonyl)-4-((4-
methoxyphenyl) sulfonyl) piperazine ([18F] DASA-23) as a novel radiopharmaceutical to …
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Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [18F]DASA-23

C Beinat, CB Patel, Y Xie, SS Gambhir - Molecular imaging and biology, 2020 - Springer
Abstract Purpose Pyruvate kinase M2 (PKM2) catalyzes the final step in glycolysis, the key
process of tumor metabolism. PKM2 is found in high levels in glioblastoma (GBM) cells with …
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Development of [18F]DASA-23 for Imaging Tumor Glycolysis Through Noninvasive Measurement of Pyruvate Kinase M2

C Beinat, IS Alam, ML James, A Srinivasan… - Molecular imaging and …, 2017 - Springer
Purpose A hallmark of cancer is metabolic reprogramming, which is exploited by cancer
cells to ensure rapid growth and survival. Pyruvate kinase M2 (PKM2) catalyzes the final …
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Human biodistribution and radiation dosimetry of [18F]DASA-23, a PET probe targeting pyruvate kinase M2

C Beinat, CB Patel, T Haywood, B Shen, L Naya… - European journal of …, 2020 - Springer
Purpose To assess the safety, biodistribution, and radiation dosimetry of the novel positron
emission tomography (PET) radiopharmaceutical 1-((2-fluoro-6-[[18 F]] fluorophenyl) …
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Development of [18F] DASA-10 for enhanced imaging of pyruvate kinase M2

MT Kendirli, R Malek, MB Silveira, C Acosta… - Nuclear Medicine and …, 2023 - Elsevier
Purpose The aim of this study was to develop a positron emission tomography (PET)
radiotracer for measuring pyruvate kinase M2 (PKM2) with improved physicochemical and …
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[PDF] ucl.ac.uk

PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2

TH Witney, ML James, B Shen, E Chang… - Science translational …, 2015 - science.org
Cancer cells reprogram their metabolism to meet increased biosynthetic demands,
commensurate with elevated rates of replication. Pyruvate kinase M2 (PKM2) catalyzes the …
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[PDF] researchgate.net

The Utility of [18F]DASA-23 for Molecular Imaging of Prostate Cancer with Positron Emission Tomography

C Beinat, T Haywood, YS Chen, CB Patel… - Molecular imaging and …, 2018 - Springer
Purpose There is a strong, unmet need for superior positron emission tomography (PET)
imaging agents that are able to measure biochemical processes specific to prostate cancer …
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Synthesis and evaluation of [11C] PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3β (GSK-3β)

EL Cole, X Shao, P Sherman, C Quesada… - Nuclear medicine and …, 2014 - Elsevier
Introduction The dysfunction of glycogen synthase kinase-3β (GSK-3β) has been implicated
in a number of diseases, including Alzheimer's disease. The ability to non-invasively …
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