PMPA for nephroprotection in PSMA-targeted radionuclide therapy of prostate cancer

C Kratochwil, FL Giesel, K Leotta, M Eder… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Radioactive ligands for the prostate-specific membrane antigen (PSMA) are under
development for therapy of metastasized prostate cancer. Since PSMA expression is also …

[HTML][HTML] Towards personalized treatment of prostate cancer: PSMA I&T, a promising prostate-specific membrane antigen-targeted theranostic agent

KLS Chatalic, S Heskamp, M Konijnenberg… - Theranostics, 2016 - ncbi.nlm.nih.gov
Prostate-specific membrane antigen (PSMA) is a well-established target for nuclear imaging
and therapy of prostate cancer (PCa). Radiolabeled small-molecule PSMA inhibitors are …

Albumin-binding PSMA ligands: implications for expanding the therapeutic window

JM Kelly, A Amor-Coarasa, S Ponnala… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Despite significant gains in the treatment of metastatic castration-resistant prostate cancer by
radioligands targeting prostate-specific membrane antigen (PSMA), 30% of patients never …

99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer

SM Hillier, KP Maresca, G Lu, RD Merkin… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and
small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent …

Investigating PSMA-targeted radioligand therapy efficacy as a function of cellular PSMA levels and intratumoral PSMA heterogeneity

K Current, C Meyer, CE Magyar, CE Mona… - Clinical Cancer …, 2020 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) targeting radioligands deliver
radiation to PSMA-expressing cells. However, the relationship between PSMA levels and …

Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen–targeted imaging agent for prostate cancer

SE Lapi, H Wahnishe, D Pham, LY Wu… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a transmembrane protein commonly found
on the surface of late-stage and metastatic prostate cancer and a well-known imaging …

225Ac-PSMA-617 for PSMA-targeted α-radiation therapy of metastatic castration-resistant prostate cancer

C Kratochwil, F Bruchertseifer, FL Giesel… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is a promising target in prostate cancer.
Recently, we started the first-in-human treatment with an α-radionuclide–labeled PSMA …

[HTML][HTML] The future of PSMA-targeted radionuclide therapy: an overview of recent preclinical research

EAM Ruigrok, WM van Weerden, J Nonnekens… - Pharmaceutics, 2019 - mdpi.com
Prostate specific membrane antigen (PSMA) has become a major focus point in the research
and development of prostate cancer (PCa) imaging and therapeutic strategies using …

Radiolabeled Small-Molecule Ligands for Prostate-Specific Membrane Antigen: In vivo Imaging in Experimental Models of Prostate Cancer

CA Foss, RC Mease, H Fan, Y Wang, HT Ravert… - Clinical cancer …, 2005 - AACR
Purpose: Prostate-specific membrane antigen (PSMA) is a cell surface protein that is
overexpressed in prostate cancer, including hormone-refractory and metastatic disease. Our …

The effects of monosodium glutamate on PSMA radiotracer uptake in men with recurrent prostate cancer: a prospective, randomized, double-blind, placebo-controlled …

S Harsini, H Saprunoff, T Alden… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic
applications in prostate cancer. However, PSMA-targeted radioligand therapy can cause …