A common quantitative output value for PET measures of β-amyloid (Aβ) binding across
tracers and methods would allow better comparison of data across sites and application of …

Abstract Purpose The Centiloid (CL) method enables quantitative values from Aβ-amyloid
(Aβ) imaging to be expressed in a universal unit providing pathological, diagnostic and …

The accurate measurement of β-amyloid (Aβ) change using amyloid PET imaging is
important for Alzheimer disease research and clinical trials but poses several unique …

Amyloid-β deposition into plaques is a pathologic hallmark of Alzheimer disease appearing
years before the onset of symptoms. Although cerebral amyloid-β deposition occurs on a …

Background Inconsistent positivity thresholds, image analysis pipelines, and quantitative
outcomes are key challenges of multisite studies using more than one β-amyloid (Aβ) …

PET amyloid imaging is increasingly used in research trials related to Alzheimer disease
and has potential as a quantitative biomarker. This study had 3 objectives: first, to describe a …

11C-Pittsburgh compound-B (11C-PiB) is the benchmark radiotracer for imaging of β-
amyloid (Aβ) plaque in Alzheimer disease (AD). 18F-labeled Aβ tracers subsequently …

18F-florbetaben is a novel 18F-labeled tracer for PET imaging of β-amyloid deposits in the
human brain. We evaluated the kinetic model–based approaches to the quantification of β …

Accurate measurement of changes in amyloid-β (Aβ) deposition over time is important in
longitudinal studies, particularly in anti-Aβ therapeutic trials. To achieve this, the optimal …

Purpose The increasing use of amyloid PET in Alzheimer's disease research and clinical
trials has motivated efforts to standardize methodology. We compared retention of the 11 C …