Validation of FAPi PET biodistribution by immunohistochemistry in patients with solid cancers: a prospective exploratory imaging study

C Mona, M Benz, F Hikmat, T Grogan, K Lueckerath… - 2021 - Soc Nuclear Med
1000 Introduction: Fibroblast activation protein (FAP)-expressing cancer associated
fibroblasts (CAFs), a major component of tumor stroma, confer treatment resistance, promote …

Abstract LB038: Validation of FAPi PET biodistribution by immunohistochemistry in patients with solid cancers: a prospective exploratory study

CE Mona, M Benz, F Hikmat, TG Grogan, K Lueckerath… - Cancer Research, 2021 - AACR
Context: Fibroblast activation protein (FAP)-expressing cancer associated fibroblasts
(CAFs), a major component of tumor stroma, confer treatment resistance, promote local …

Validation of FAPi PET biodistribution by immunohistochemistry in patients with solid cancers: A prospective exploratory study.

C Mona, MR Benz, F Hikmat, T Grogan, K Lueckerath… - 2021 - ascopubs.org
3066 Background: Fibroblast activation protein (FAP)-expressing cancer-associated
fibroblasts (CAF), a major component of tumor stroma, confer treatment resistance, promote …

Correlation of 68Ga-FAPi-46 PET biodistribution with FAP expression by immunohistochemistry in patients with solid cancers: interim analysis of a prospective …

CE Mona, MR Benz, F Hikmat, TR Grogan… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Fibroblast activation protein (FAP)–expressing cancer-associated fibroblasts confer
treatment resistance and promote metastasis and immunosuppression. Because FAP is …

The evolving role of FAPI-PET in assessing patients with various malignancies and its potential superiority over FDG-PET in this setting

S Singh, NK Khurana, B Saboury, T Werner, A Alavi… - 2022 - Soc Nuclear Med
2711 Introduction: Fibroblast activation protein (FAP) is overexpressed in cancer-associated
fibroblasts (CAFs) of many human epithelial cancers and more in tumors with high grades of …

Imaging with 68Ga-FAPI PET/CT: Results from a FAPI Registry Study

N Hirmas, M Sraieb, L Kessler, KM Pabst… - World Journal of …, 2022 - thieme-connect.com
Background: FAPI ligands (fibroblast activation protein inhibitor), a novel class of
radiotracers for PET/CT imaging, demonstrated promising preclinical and clinical results …

Radiation dosimetry and biodistribution of 68Ga-FAPI-46 PET imaging in cancer patients

C Meyer, M Dahlbom, T Lindner, S Vauclin… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Targeting cancer-associated fibroblasts (CAFs) has become an attractive goal for diagnostic
imaging and therapy because they can constitute as much as 90% of a tumor mass. The …

Imaging with Ga-68-FAPI PET/CT: Results from a FAPI Registry Study

N Hirmas, M Sraieb, L Kessler, KM Pabst… - Nuklearmedizin …, 2022 - thieme-connect.com
Ziel/Aim FAPI ligands (fibroblast activation protein inhibitor), a novel class of radiotracers for
PET/CT imaging, demonstrated promising preclinical and clinical results. FAP is …

Ga-68-FAPI for sarcoma imaging: Data from the FAPI-PET prospective observational trial

L Kessler, R Hamacher, J Ferdinandus, F Zarrad… - 2021 - Soc Nuclear Med
126 Introduction: Bone and soft tissue tumors are of mesenchymal origin and have been
shown to express fibroblast activation protein (FAP) in tumor cells and cancer-associated …

[HTML][HTML] Imaging cancer-associated fibroblasts (CAFs) with FAPi PET

L Gilardi, LS Airò Farulla, E Demirci, I Clerici… - Biomedicines, 2022 - mdpi.com
The tumor microenvironment (TME) surrounding tumor cells is a complex and highly
dynamic system that promotes tumorigenesis. Cancer-associated fibroblasts (CAFs) are key …