An 89Zr-HDL PET tracer monitors response to a CSF1R inhibitor
The immune function within the tumor microenvironment has become a prominent
therapeutic target, with tumor-associated macrophages (TAMs) playing a critical role in …
therapeutic target, with tumor-associated macrophages (TAMs) playing a critical role in …
PET imaging of tumor-associated macrophages with 89Zr-labeled high-density lipoprotein nanoparticles
C Pérez-Medina, J Tang, D Abdel-Atti… - Journal of nuclear …, 2015 - Soc Nuclear Med
Tumor-associated macrophages (TAMs) are increasingly investigated in cancer immunology
and are considered a promising target for better and tailored treatment of malignant growth …
and are considered a promising target for better and tailored treatment of malignant growth …
Immuno-PET Detects Antibody–Drug Potency on Coadministration with Statins
EL Brown, S Shmuel, K Mandleywala… - Journal of Nuclear …, 2023 - Soc Nuclear Med
The human epidermal growth factor receptor 2 (HER2)–targeting trastuzumab emtansine (T-
DM1) and trastuzumab deruxtecan (T-DXd) are antibody–drug conjugates (ADC) clinically …
DM1) and trastuzumab deruxtecan (T-DXd) are antibody–drug conjugates (ADC) clinically …
[HTML][HTML] Potential PET tracers for imaging of tumor-associated macrophages
The increasing incidence of cancer over the years is one of the most challenging problems
in healthcare. As cancer progresses, the recruitment of several immune cells is triggered …
in healthcare. As cancer progresses, the recruitment of several immune cells is triggered …
[HTML][HTML] Positron emission tomography imaging of macrophages in cancer
CC Parker, SE Lapi - Cancers, 2021 - mdpi.com
Simple Summary Tumor-associated macrophages (TAMs) play numerous roles in cancer
biology and are an important component of the relationship between immune system …
biology and are an important component of the relationship between immune system …
CD8+ T-Cell Density Imaging with 64Cu-Labeled Cys-Diabody Informs Immunotherapy Protocols
JW Seo, R Tavaré, LM Mahakian, MT Silvestrini… - Clinical Cancer …, 2018 - AACR
Purpose: Noninvasive and quantitative tracking of CD8+ T cells by PET has emerged as a
potential technique to gauge response to immunotherapy. We apply an anti-CD8 cys …
potential technique to gauge response to immunotherapy. We apply an anti-CD8 cys …
[HTML][HTML] CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma
Purpose: Multiple myeloma is a plasma cell malignancy with an unmet clinical need for
improved imaging methods and therapeutics. Recently, we identified CD46 as an …
improved imaging methods and therapeutics. Recently, we identified CD46 as an …
Phase I study of [68Ga] Ga-Anti-CD206-sdAb for PET/CT assessment of protumorigenic macrophage presence in solid tumors (MMR phase I)
Macrophages play an important role throughout the body. Antiinflammatory macrophages
expressing the macrophage mannose receptor (MMR, CD206) are involved in disease …
expressing the macrophage mannose receptor (MMR, CD206) are involved in disease …
Imaging the cancer immune environment and its response to pharmacologic intervention, Part 2: The role of novel PET agents
Although 18F-FDG PET/CT is widely available and is increasingly being used to monitor
response to immunotherapy and simultaneously identify immune-related adverse events …
response to immunotherapy and simultaneously identify immune-related adverse events …
PET imaging of macrophage mannose receptor–expressing macrophages in tumor stroma using 18F-radiolabeled camelid single-domain antibody fragments
A Blykers, S Schoonooghe, C Xavier… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Tumor-associated macrophages constitute a major component of the stroma of solid tumors,
encompassing distinct subpopulations with different characteristics and functions. We aimed …
encompassing distinct subpopulations with different characteristics and functions. We aimed …